Popular Weight-Loss drugs may change Pre-Surgery fasting rules

NCT ID NCT07140289

ENROLLING_BY_INVITATION Knowledge-focused Sponsor: Wael Saasouh, MD Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 17, 2026 · Updated 2 times

Summary

This study looks at how GLP-1 receptor agonists (like Ozempic or Wegovy) affect how fast the stomach empties before surgery. These drugs are used for weight loss and diabetes, but they slow stomach emptying, which could raise the risk of food or liquid entering the lungs during anesthesia. Researchers will use ultrasound to measure stomach contents in 100 patients taking GLP-1 drugs before elective surgery. The goal is to find out if these patients need longer fasting times to stay safe.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs)
What this could lead to
If successful, this could lead to specific fasting guidelines for patients on GLP-1 drugs before surgery, reducing the risk of aspiration.
What could go wrong
This is a small, early observational study (100 participants) that only measures stomach size by ultrasound, not actual aspiration events. Results may not apply to all patients or surgeries.

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Conditions

The condition(s) this trial relates to.

aspiration pneumonia gastroparesis Intermittent Fasting Respiratory Aspiration of Gastric Contents

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Detroit Medical Center

    Detroit, Michigan, 482001, United States

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