Could a diabetes drug shield your brain from stroke and dementia?

NCT ID NCT05356104

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a GLP-1 drug, already used for diabetes, can slow down small vessel disease in the brain—a major cause of stroke, dementia, and mobility issues. About 110 adults aged 55 to 80 with moderate-to-severe disease will receive the drug or a placebo. The goal is to see if it can prevent worsening of brain damage and thinking problems.

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Conditions

The condition(s) this trial relates to.

Cerebral Small Vessel Diseases

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Chinese University of Hong Kong

    RECRUITING

    Hong Kong, Hong Kong

  • First Affiliated Hospital of Wenzhou Medical University

    RECRUITING

    Wenzhou, Zhejiang, China

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