Gene hunt aims to solve mysterious fetal swelling disorder

NCT ID NCT05528796

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks for genetic causes of non-immune hydrops fetalis, a condition where fluid builds up abnormally in a fetus, leading to high risks of stillbirth or death. Researchers will use whole genome sequencing on 500 affected fetuses or newborns and their parents. The goal is to find hidden genetic diseases to improve prenatal care and outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to

If successful, this could lead to better diagnosis and targeted care for pregnancies affected by non-immune hydrops fetalis, potentially improving survival and outcomes.

What could go wrong

This is an observational study, not a treatment trial. It may not find causes for all cases, and results may take years to impact clinical practice.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

hydrops fetalis non-immune hydrops fetalis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of California, San Francisco

    San Francisco, California, 94143, United States