Non-immune hydrops fetalis
MONDO:0009369Non-immune hydrops fetalis (NIHF), a form of HF, is a severe fetal condition defined as the excessive accumulation of fetal fluid within the fetal extravascular compartments and body cavities, and is the end-stage of a wide variety of disorders.
Also known as: non-immune HF, non-immune fetal edema, non-immune fetal hydrops, non-immune foetal hydrops, non-immune foetal oedema, Haemoglobin H hydrops fetalis syndrome, Hemoglobin H hydrops fetalis syndrome, NIHF
9 clinical trials for this condition and its sub-types.
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New genetic sleuthing could solve mysterious fetal swelling cases
Diagnosis Recruiting nowThis study tests whether whole exome and whole genome sequencing can uncover genetic causes of nonimmune fetal hydrops—a serious condition where fluid builds up in a fetus—when standard tests find nothing. Researchers will analyze DNA from 55 affected fetuses or newborns and thei…
Sponsor: Thomas Jefferson University • Aim: Diagnosis
Last updated Jun 26, 2026 15:42 UTC
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Scientists map DNA 'Signatures' in rare fetal diseases
Knowledge-focused Recruiting nowThis study looks at DNA methylation patterns (chemical tags on DNA) in fetuses with rare genetic diseases. Researchers will analyze DNA from amniotic fluid and tissue samples to create reference signatures. The goal is to improve diagnosis of these conditions before birth. The st…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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Gene tests for sick newborns: a lifesaver in the NICU?
Knowledge-focused Recruiting nowThis study is testing whether using rapid genetic sequencing can help doctors diagnose and treat birth defects in newborns in intensive care. Researchers will enroll 2,000 babies and compare death rates, disability rates, and genetic findings. The goal is to see if personalized t…
Sponsor: Children's Hospital of Fudan University • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:36 UTC