Gene therapy shot aims to cut eye injections for diabetic vision loss
NCT ID NCT05930561
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This phase 2 trial tests a gene therapy called 4D-150 for diabetic macular edema, a condition that causes vision loss in people with diabetes. The study involves 72 adults who will receive either the gene therapy or standard aflibercept injections. The goal is to see if a single dose of gene therapy can reduce the need for frequent eye injections over two years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- 4D-150 gene therapy
- What this could lead to
- If successful, this gene therapy could reduce the number of eye injections needed to control diabetic macular edema, potentially improving quality of life.
- What could go wrong
- This is an early phase 2 trial with only 72 participants. The therapy may not work as hoped, and there are risks from the injection and gene therapy itself.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Austin Clinical Research
Austin, Texas, 78750, United States
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Cumberland Valley Retina Consultants
Hagerstown, Maryland, 21740, United States
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Emanuelli Research and Development Center
Arecibo, X00612, Puerto Rico
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Erie Retina Research
Erie, Pennsylvania, 16507, United States
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Piedmont Eye Center
Lynchburg, Virginia, 24502, United States
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Verum Research, LLC
Eugene, Oregon, 97401, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- AI eye doctor: could software catch diabetic blindness sooner?
- Can a new eye injection preserve vision in south asians with diabetes?
- Can eye scans reveal hidden clues about diabetes damage?
- Could a biosimilar eye injection offer a new way to treat diabetic macular edema?
- Can a steroid implant boost the effect of standard eye injections for hard-to-treat diabetic macular edema?
- Eye injection aims to tame leading causes of blindness