Constipation drugs may reveal new clues about gut health in Barrett's esophagus patients
NCT ID NCT05107219
First seen Oct 31, 2025 · Last updated May 06, 2026 · Updated 27 times
Summary
This early study looked at whether two FDA-approved constipation drugs, plecanatide and linaclotide, change levels of a chemical called cGMP in the small intestine. Researchers compared tissue samples from 43 adults with Barrett esophagus or GERD who took one of the drugs or no drug. The goal was to understand how these drugs work in the gut, not to treat the disease.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States
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Mayo Clinic in Arizona
Scottsdale, Arizona, 85259, United States
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Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107, United States
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University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, 53792, United States
Conditions
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