Does food change how this heart pill works? new study investigates
NCT ID NCT07043634
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed Phase 3 study in 24 healthy adults examines whether taking a fixed-dose combination of extended-release torsemide and spironolactone with or without food changes how the body absorbs the drugs. Participants receive a single dose under both conditions, and researchers measure drug levels in blood and urine. The goal is to guide dosing instructions for this heart failure medication.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
torsemide and spironolactone combination pill
What this could lead to
If it works, this could help doctors know whether to take this pill with or without food for best absorption.
What could go wrong
This is a small, early-stage study in healthy volunteers, not patients. Results may not apply to people with heart or kidney conditions who would actually use the drug.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Sarfez Pharmaceuticals
Vienna, Virginia, 22182, United States