Could a vitamin help kids with autism? new trial tests folinic acid
NCT ID NCT07642661
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether folinic acid (a form of vitamin B9) can reduce irritability and improve behavior in 150 children aged 3 to 6 with autism. Half will get folinic acid, half a placebo, for 9 weeks. Researchers will also check if it helps with communication, sleep, and gut symptoms. The goal is to see if this supplement is safe and effective for core autism symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
folinic acid (leucovorin)
What this could lead to
If it works, this could point toward a safe, well-tolerated supplement to ease irritability and behavioral symptoms in young children with autism.
What could go wrong
This is a small, early-phase trial (Phase 2) with only 150 kids over 9 weeks. Previous studies were mixed, and the placebo effect can be strong in behavioral trials. It may not show clear benefit.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Shaare Zedek Medical Center
RECRUITINGJerusalem, N/A = Not Applicable, 9103102, Israel
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••