Could a vitamin help kids with autism? new trial tests folinic acid

NCT ID NCT07642661

Recruiting now Symptom relief Sponsor: Prof. Adi Aran Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether folinic acid (a form of vitamin B9) can reduce irritability and improve behavior in 150 children aged 3 to 6 with autism. Half will get folinic acid, half a placebo, for 9 weeks. Researchers will also check if it helps with communication, sleep, and gut symptoms. The goal is to see if this supplement is safe and effective for core autism symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: folinic acid (leucovorin)
What this could lead to: If it works, this could point toward a safe, well-tolerated supplement to ease irritability and behavioral symptoms in young children with autism.
What could go wrong: This is a small, early-phase trial (Phase 2) with only 150 kids over 9 weeks. Previous studies were mixed, and the placebo effect can be strong in behavioral trials. It may not show clear benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autism autism spectrum disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTISM SPECTRUM DISORDER

Contacts and locations

Locations

Shaare Zedek Medical Center
RECRUITING

Jerusalem, N/A = Not Applicable, 9103102, Israel

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