Throat spray may ease pain after breathing tube use
NCT ID NCT07163429
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether spraying a painkiller (flurbiprofen) onto a breathing tube before surgery can reduce sore throat and hoarseness afterward. 58 adults having elective lung surgery will receive either the active spray or a placebo. Their symptoms will be checked at several time points up to 48 hours after surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- flurbiprofen spray
- What this could lead to
- If it works, this could offer a simple way to prevent sore throat and hoarseness after certain types of lung surgery.
- What could go wrong
- This is a small, early-stage trial with only 58 people. The results may not apply to everyone, and the spray might not work better than placebo.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 58 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2025
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient aged 20-80 years * Undergoing elective thoracic surgery * Requiring DLT intubation for lung separation * ASA physical status classification I-III * Able to communicate and understand the study Exclusion Criteria: * Contraindications to use of flurbiprofen, including allergies to flurbiprofen or NSAIDs, active peptic ulcer/ hemorrhage, history of gastrointestinal bleeding or perforation, severe colitis, severe heart failure, chronic kidney disease (CKD) stage IV or end-stage kidney disease (ESRD), or liver failure * Recent or recurrent upper respiratory tract infection * History of sore throat or hoarseness within 1 month prior to surgery * History of previous airway surgery * Chronic pain conditions * Pregnancy Withdrawal criteria * Fail DLT intubation * Inability to extubation at the end of surgery
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Maharaj Nakorn Chiang Mai Hospital, Faculty of Medicine, Chiang Mai University
Chiang Mai, Mueang, 50200, Thailand
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