Scientists compare FluMist and flu shot immune responses in nose and lungs

NCT ID NCT07177417

Recruiting now Knowledge-focused Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looks at how two FDA-approved flu vaccines—FluMist (a nasal spray) and the standard flu shot—trigger immune responses in healthy adults aged 18 to 40. Researchers will measure antibodies in the blood, nose, and lungs before and after vaccination. Some participants will also undergo a bronchoscopy to sample lung tissue. The goal is to better understand how these vaccines protect the upper and lower airways.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: FluMist (live attenuated influenza vaccine) and Fluarix (inactivated influenza vaccine)
What this could lead to: If successful, this study could help scientists understand how flu vaccines trigger immunity in the lungs and nose, potentially leading to better vaccines.
What could go wrong: This is a small, early-stage study (30 people) focused on measuring immune markers, not on preventing flu. Results may not apply to the general population.

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Conditions

The condition(s) this trial relates to.

influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY YOUNG ADULTS INFLUENZA VACCINE RESPONSE INFLUENZA VACCINES

Contacts and locations

Locations

Washington University in Saint Louis School of Medicine Emergency Care and Research Core
RECRUITING

St Louis, Missouri, 63110, United States

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