Fish oil fails to deliver in nerve damage trial

NCT ID NCT05145452

Terminated Disease control Sponsor: University of Missouri-Columbia Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether high-dose fish oil supplements could improve nerve function in people with prediabetes and early diabetic neuropathy. Researchers planned to enroll 40 adults aged 55–80, but the trial was terminated early with only 31 participants. Participants took either fish oil pills or a placebo for six months, and nerve function was measured at three and six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: fish oil (n-3 polyunsaturated fatty acids)
What this could lead to: If it works, this could point toward a simple dietary supplement to help manage nerve damage from diabetes.
What could go wrong: This was a small, early trial that was terminated, so results are limited. Fish oil may not improve nerve function, and high doses can cause side effects like fishy aftertaste or digestive issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diabetic neuropathy prediabetes syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC NEUROPATHIES

Contacts and locations

Locations

Washington University

St Louis, Missouri, 63110, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States

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