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New drug could cool menopause hot flashes without hormones

NCT ID NCT06206408

Completed Symptom relief Sponsor: Astellas Pharma Inc Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested fezolinetant, a non-hormonal medicine, in 410 Japanese women with menopause-related hot flashes. Participants took either a low or high dose of fezolinetant or a placebo daily for 12 weeks. The goal was to see if the drug reduces the number and severity of hot flashes compared to placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

fezolinetant

What this could lead to

If it works, this could provide a non-hormonal option to reduce hot flashes for Japanese women going through menopause.

What could go wrong

This is a completed Phase 3 trial, but results may not apply to all women. Fezolinetant is already approved in the US, but its effectiveness and safety in Japanese women are still being confirmed.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Hot Flashes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HOT FLASHES

Contacts and locations

Locations

  • Aiiku Ladies Clinic

    Funabashi-shi, Chiba, Japan

  • Asahi Clinic

    Takamatsu, Kagawa-ken, Japan

  • Chayamachi Ladies Clinic

    Osaka, Osaka, Japan

  • Chiba Aoba Municipal Hospital

    Chiba, Chiba, Japan

  • Chieko Yukika Lady's Clinic

    Sendai, Miyagi, Japan

  • Chiharu Clinic

    Osaka, Osaka, Japan

  • Chita Kosei Hospital

    Chita-gun, Aichi-ken, Japan

  • Daido Clinic

    Nagoya, Aichi-ken, Japan

  • Fukuoka Mirai Hospital

    Fukuoka, Fukuoka, Japan

  • GyNet Medical Corporation Minamimorimachi Ladies' Clinic

    Osaka, Osaka, Japan

  • JA Toride Medical Center

    Toride, Ibaraki, Japan

  • Japan Community Health care Organization Tokuyama Central Hospital

    Shunan-shi, Yamaguchi, Japan

  • Juno Vesta Clinic hatta

    Matsudo-shi, Chiba, Japan

  • Kawasakieki Fumi Ladies Clinic

    Kawasaki-shi, Kanagawa, Japan

  • Kichijyoji Ladies Clinic

    Musashino-shi, Tokyo, Japan

  • Kitahorie Kanade Ladies Clinic

    Osaka, Osaka, Japan

  • Komorebi Ladies Clinic Osaka Honmachi

    Osaka, Osaka, Japan

  • Konan Kosei Hospital

    Kōnan, Aichi-ken, Japan

  • Kosumo Clinic

    Kako-gun, Hyōgo, Japan

  • Kotoni Ladies Clinic

    Sapporo, Hokkaido, Japan

  • Koukan Clinic

    Kawasaki-shi, Kanagawa, Japan

  • M's Ladies Clinic

    Sapporo, Hokkaido, Japan

  • MEITETSU Hospital

    Nagoya, Aichi-ken, Japan

  • Machida Municipal Hospital

    Machida-shi, Tokyo, Japan

  • Mari Women'S Clinic

    Nisinomiya-shi, Hyōgo, Japan

  • Marunouchi no Mori Ladies Clinic

    Chiyoda-ku, Tokyo, Japan

  • Maruyama Memorial General Hospital

    Saitama-shi, Saitama, Japan

  • Medical Corp. SEIKOUKAI New Medical Research System Clinic

    Hachioji-shi, Tokyo, Japan

  • Medical Corporation Asbo Tokyo Asbo Clinic

    Chuo-ku, Tokyo, Japan

  • Medical Corporation Associa Tamacenter Ladies Clinic

    Tama-Shi, Tokyo, Japan

  • Miyabi Uro-Gyne Clinic

    Okayama, Okayama-ken, Japan

  • Miyanomori Ladies' Clinic

    Sapporo, Hokkaido, Japan

  • Mori Ladies Clinic

    Fukuoka, Fukuoka, Japan

  • Motomachi Ladies Clinic

    Yokohama, Kanagawa, Japan

  • NISHIKAWA Women's Health Clinic

    Sapporo, Japan

  • National Hospital Organization Beppu Medical Center

    Beppu-shi, Oita Prefecture, Japan

  • National Hospital Organization Kanazawa Medical Center

    Kanazawa, Ishikawa-ken, Japan

  • National Hospital Organization Osaka Minami Medical Center

    Kawachinagano-shi, Osaka, Japan

  • National Hospital Organization Takasaki General Medical Center

    Takasaki-shi, Gunma, Japan

  • Ninomiya Ladies Clinic

    Osaka, Osaka, Japan

  • Nishiguchi Clinic Fujinka

    Fukushima, Fukushima, Japan

  • OHARA Clinic

    Saitama, Saitama, Japan

  • Omi Medical Center, Social Medical Corporation Seikoukai

    Kusatsu-shi, Shiga, Japan

  • Omihachiman Community Medical Center

    Ōmihachiman, Shiga, Japan

  • Rakuwakai Otowa Hospital

    Kyoto, Kyoto, Japan

  • Rikako Ladies Clinic

    Osaka, Osaka, Japan

  • Sadamori Ladies Clinic

    Hiroshima, Hiroshima, Japan

  • Sato Hospital

    Takasaki-shi, Gunma, Japan

  • Sei Women's Clinic

    Bunkyo-ku, Tokyo, Japan

  • Shimamura Memorial Hospital

    Nerima-ku, Tokyo, Japan

  • Shimizu Ladies Clinic

    Sakai-shi, Osaka, Japan

  • Shimodaira Ladies Clinic

    Suginami-ku, Tokyo, Japan

  • Shinkawasaki Kobiki Womens Clinic

    Kawasaki-shi, Kanagawa, Japan

  • Shonan Kamakura General Hospital

    Kamakura, Kanagawa, Japan

  • Social Medical Care Corporation Hosei-kai Marunouchi Hospital

    Matsumoto-shi, Nagano, Japan

  • Social Medical Corporation Caress Sapporo Caress Memorial Hospital

    Sapporo, Hokkaido, Japan

  • Tennoji Chihiro Women's Clinic

    Osaka, Osaka, Japan

  • Toranomon Womens Clinic

    Minato-ku, Tokyo, Japan

  • Toyota Kosei Hospital

    Toyota-shi, Aichi-ken, Japan

  • Tsujinaka Hospital Kashiwanoha

    Kashiwa-shi, Chiba, Japan

  • Tsukuba Urocare Clinic

    Tsukuba, Ibaraki, Japan

  • Women's Clinic LUNA Yokohama Motomachi

    Yokohama, Kanagawa, Japan

  • Yukawa Women'S Clinic

    Nishi-Tokyo-shi, Tokyo, Japan

  • jMOG Medical Corporation Tanabe Ladies' Clinic

    Takatsuki-shi, Osaka, Japan