New pill could cool menopause hot flashes without hormones
NCT ID NCT06812754
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether fezolinetant, a non-hormonal drug, can reduce moderate to severe hot flashes in Chinese women going through menopause. About 150 women will take either fezolinetant or a placebo daily for 12 weeks. The goal is to see if the drug safely eases symptoms, offering an alternative to hormone therapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- fezolinetant
- What this could lead to
- If successful, this could provide a non-hormonal treatment option for hot flashes in Chinese women going through menopause.
- What could go wrong
- This is a small, early-phase trial (150 participants) with a placebo control. Results may not confirm effectiveness or safety for broader use.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Beijing Hospital
Beijing, Beijing Municipality, China
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Capital Medical University (CMU) - Beijing Shijitan Hospital
Beijing, Beijing Municipality, China
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Capital Medical University - Beijing Obstetrics and Gynecology Hospital
Beijing, Beijing Municipality, China
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Chengdu Women's and Children's Central Hospital
Chengdu, Sichuan, China
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Guangxi Medical University (GXMU) - Liuzhou Renmin Hospital
Liuzhou, Guangxi, China
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Guangzhou Medical University - The Third Affiliated Hospital
Guangzhou, Guangdong, China
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Hainan Women and Children's Medical Center
Haikou, Hainan, China
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Hunan Provincial Maternal and Child Health Care Hospital
Changsha, Hunan, China
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Jiangxi Maternal and Child Health Hospital
Nanchang, Jiangxi, China
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Jilin Province FAW General Hospital
Changchun, Jilin, China
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Jinan Central Hospital Affiliated to Shandong First Medical University
Jinan, Shandong, China
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Liuzhou Worker's Hospital
Liuzhou, Guangxi, China
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Nanjing First Hospital
Nanjing, Jiangsu, China
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Peking Union Medical College Hospital
Beijing, Beijing Municipality, China
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Peking University Shenzhen Hospital
Shenzhen, Guangdong, China
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Shandong Provincial Hospital
Jinan, Shandong, China
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Shanghai First Maternity and Infant Hospital
Shanghai, Shanghai Municipality, China
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Shanxi Woman and Children Hospital
Taiyuan, Shanxi, China
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Shenzhen Maternal & Child Health Hospital
Shenzhen, Guangdong, China
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Southeast University, ZhongDa Hospital
Nanjing, Jiangsu, China
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Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
Guangzhou, Guangdong, China
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The First hospital of Shanxi Medical University
Taiyuan, Shanxi, China
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The Second Hospital of Tianjin Medical University
Tianjin, Tianjin Municipality, China
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The second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
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Xiangya Hospital, Central South University
Zhuzhou, Hunan, China
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Zhujiang Hospital of Southern Medical University
Guangzhou, Guangdong, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A cool wristband takes on hot flashes — no drugs needed
- Could a cold shower cool menopausal hot flashes?
- Hot flashes linked to heart risk? mayo clinic investigates
- New drug fezolinetant tested for hot flash relief in everyday life
- Needles vs. night sweats: acupuncture trial targets hot flashes in prostate cancer patients
- Hot flushes may do more than make you sweat – new study looks at heart impact