Eye injection vs. surgery: which is better for diabetic retinopathy?

NCT ID NCT06790784

Recruiting now Disease control Sponsor: Jaeb Center for Health Research Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 2 times

Summary

This study tests two ways to treat proliferative diabetic retinopathy, a serious eye problem caused by diabetes. One group gets eye injections of faricimab plus laser treatment; the other gets vitrectomy surgery with laser. Researchers will track vision and how many extra treatments are needed over 3 years. About 426 adults with diabetes are being recruited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: faricimab (injection) and panretinal photocoagulation (laser) vs. vitrectomy (surgery) and endolaser
What this could lead to: If successful, this could show that a less invasive injection-plus-laser approach works as well as or better than surgery for advanced diabetic eye disease.
What could go wrong: This is a phase 3 trial, but results may not apply to all patients. Both treatments have risks like infection, bleeding, or vision loss, and the injection group may need more follow-up treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

proliferative diabetic retinopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROLIFERATIVE DIABETIC RETINOPATHY (PDR)

Contacts and locations

Locations

Austin Research Center for Retina
RECRUITING

Austin, Texas, 78705, United States
Baylor College of Medicine, Baylor Eye Physicians and Surgeons
RECRUITING

Houston, Texas, 77030-4101, United States
Boston Medical Center Corporation
RECRUITING

Boston, Massachusetts, 02118, United States
California Retina Consultants
RECRUITING

Santa Barbara, California, 93103-4223, United States
Elman Retina Group, P.A.
RECRUITING

Baltimore, Maryland, 21237, United States
Emory Eye Center
RECRUITING

Atlanta, Georgia, 30322, United States
Florida Retina Consultants
RECRUITING

Lakeland, Florida, 33805, United States
Illinois Retina Associates SC Oak Park Site
RECRUITING

Oak Park, Illinois, 60304, United States
Joseph E. Humble and Raymond Haik PTRS DBA Eye Assoc of Northeast Louisiana
RECRUITING

West Monroe, Louisiana, 71291-4452, United States
Joslin Diabetes Center
RECRUITING

Boston, Massachusetts, 02215, United States
Loma Linda University
RECRUITING

Loma Linda, California, 92354, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Mid-America Retina Consultants, P.A.
RECRUITING

Overland, Kansas, 66211, United States
Midwest Eye Institute
RECRUITING

Carmel, Indiana, 46032, United States
Ophthalmic Partners of Florida, PA dba Central Florida Retina
RECRUITING

Orlando, Florida, 32806, United States
Retina Associates of Florida, LLC
RECRUITING

Tampa, Florida, 33609, United States
Retina Associates of Southern California
RECRUITING

Huntington Beach, California, 92647, United States
Retina Associates of Western NY, P.C.
RECRUITING

Rochester, New York, 14620, United States
Retina Consultants of Minnesota
RECRUITING

Saint Louis Park, Minnesota, 55416, United States
Retina Consultants of Texas, PA
RECRUITING

Bellaire, Texas, 77401, United States
Retina Research Institute, LLC
RECRUITING

St Louis, Missouri, 63128, United States
Retina Vitreous Center
RECRUITING

Edmond, Oklahoma, 73013, United States
Retina-Vitreous Consultants, Inc.
RECRUITING

Monroeville, Pennsylvania, 15146, United States
Southeast Retina Center, P.C.
RECRUITING

Augusta, Georgia, 30909, United States
Texas Retina Associates
RECRUITING

Lubbock, Texas, 79424, United States
The Trustees of Indiana University
RECRUITING

Indianapolis, Indiana, 46202, United States
University of Florida - Jacksonville
RECRUITING

Jacksonville, Florida, 32209, United States
University of Kentucky Advanced Eye Care
RECRUITING

Lexington, Kentucky, 40508, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27517-8923, United States
Wolfe Clinic, P.C.- West Des Moines
RECRUITING

West Des Moines, Iowa, 50266, United States

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