Last-Resort leukemia treatment made available through expanded access program

NCT ID NCT06799221

AVAILABLE Disease control Sponsor: Autolus Limited Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This expanded access program provides an experimental CAR-T cell therapy called obe-cel to adults with relapsed or refractory B-cell acute lymphoblastic leukemia (ALL) who have no other treatment options. The therapy is made from the patient's own blood cells but did not meet commercial quality standards. The program aims to offer a potential lifeline while monitoring safety and side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: obecabtagene autoleucel (obe-cel), a CAR-T cell therapy made from the patient's own immune cells
What this could lead to: If this program works, it could offer a treatment option for people with hard-to-treat leukemia who have run out of standard choices.
What could go wrong: This is an early access program, not a formal trial, so results are uncertain. The product is out-of-specification, meaning it may be less effective or carry unknown risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adult acute lymphoblastic leukemia B-cell acute lymphoblastic leukemia Burkitt lymphoma Precursor Cell Lymphoblastic Leukemia-Lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

B CELL ALL LYMPHOBLASTIC LEUKEMIA, ACUTE, ADULT

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Banner MD Anderson Cancer Center
AVAILABLE

Gilbert, Arizona, 85234, United States
Baylor Scott & White Research Institute
AVAILABLE

Dallas, Texas, 75246, United States
City of Hope National Medical Center
AVAILABLE

Duarte, California, 93534, United States
City of Hope Phoenix
AVAILABLE

Phoenix, Arizona, 85338, United States
Cleveland Clinic
AVAILABLE

Cleveland, Ohio, 44195, United States
Colorado Blood Cancer Institute
AVAILABLE

Denver, Colorado, 80218, United States
Dana-Farber Cancer Institute
AVAILABLE

Boston, Massachusetts, 02115, United States
Emory
AVAILABLE

Atlanta, Georgia, 30322, United States
Hackensack University Medical Center
AVAILABLE

Hackensack, New Jersey, 07601, United States
Houston Methodist Hospital
AVAILABLE

Houston, Texas, 77030, United States
Kansas University Medical Center
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Kansas City, Kansas, 66160, United States
MCW Froedtert
AVAILABLE

Milwaukee, Wisconsin, 53226, United States
MD Anderson Cancer Center
AVAILABLE

Houston, Texas, 77030, United States
Massachusetts General Hospital
AVAILABLE

Boston, Massachusetts, 02114, United States
Medical City Dallas
AVAILABLE

Dallas, Texas, 75230, United States
Memorial Sloan Kettering Cancer Center
AVAILABLE

New York, New York, 10065, United States
NYU-Langone
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New York, New York, 10016, United States
Oregon Health and Science University
AVAILABLE

Portland, Oregon, 97239, United States
Orlando Health
AVAILABLE

Orlando, Florida, 32806, United States
St. David's South Austin Medical Center
AVAILABLE

Austin, Texas, 78704, United States
Stanford University
AVAILABLE

Palo Alto, California, 94304, United States
Texas Transplant Institute
AVAILABLE

San Antonio, Texas, 78229, United States
The Ohio State University
AVAILABLE

Columbus, Ohio, 43202, United States
TriStar Centennial Medical Center (SCRI)
AVAILABLE

Nashville, Tennessee, 37203, United States
University of California San Diego Health (UCSD)
AVAILABLE

La Jolla, California, 92093, United States
University of California San Francisco (UCSF)
AVAILABLE

San Francisco, California, 94143, United States
University of Iowa
AVAILABLE

Iowa City, Iowa, 52242, United States
University of Maryland Medical Center
AVAILABLE

Baltimore, Maryland, 21201, United States
University of Minnesota
AVAILABLE

Minneapolis, Minnesota, 55455, United States
University of Pennsylvania
AVAILABLE

Philadelphia, Pennsylvania, 19104, United States
Vanderbilt University Medical Center
AVAILABLE

Nashville, Tennessee, 37232, United States
Washington University School of Medicine
AVAILABLE

Seattle, Washington, 98195, United States

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