Exercise and diet may protect the brain during CAR-T cancer treatment

NCT ID NCT07173166

Recruiting now Symptom relief Sponsor: Instituto de Investigacion Sanitaria INCLIVA Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 29, 2026 · Updated 3 times

Summary

This study tests whether a structured exercise program, with or without nutritional advice, can lower the risk and severity of neurotoxicity (brain-related side effects) caused by CAR-T cell therapy in adults with blood cancers. One hundred participants will be randomly assigned to exercise, exercise plus diet, or usual care. The goal is to find a non-drug way to improve recovery and reduce cognitive problems.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: structured physical activity program and nutritional recommendations
What this could lead to: If it works, this could offer a simple, drug-free way to reduce brain-related side effects from CAR-T therapy, improving recovery and quality of life.
What could go wrong: This is an early-stage trial with only 100 participants, so results may not apply to everyone. The interventions are supportive and may not prevent severe neurotoxicity.

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Conditions

The condition(s) this trial relates to.

hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm Motor Activity toxic encephalopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMATOLOGIC CANCER

Contacts and locations

Locations

Hospital Clínico Universitario de Valencia
RECRUITING

Valencia, Valencia, 46010, Spain
Hospital Universitario y Politécnico La Fe
RECRUITING

Valencia, Valencia, 46026, Spain

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