Exercise and diet may protect the brain during CAR-T cancer treatment

NCT ID NCT07173166

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a structured exercise program, with or without nutritional advice, can lower the risk and severity of neurotoxicity (brain-related side effects) caused by CAR-T cell therapy in adults with blood cancers. One hundred participants will be randomly assigned to exercise, exercise plus diet, or usual care. The goal is to find a non-drug way to improve recovery and reduce cognitive problems.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

structured physical activity program and nutritional recommendations

What this could lead to

If it works, this could offer a simple, drug-free way to reduce brain-related side effects from CAR-T therapy, improving recovery and quality of life.

What could go wrong

This is an early-stage trial with only 100 participants, so results may not apply to everyone. The interventions are supportive and may not prevent severe neurotoxicity.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm Motor Activity toxic encephalopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Hospital Clínico Universitario de Valencia

    RECRUITING

    Valencia, Valencia, 46010, Spain

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hospital Universitario y Politécnico La Fe

    ACTIVE_NOT_RECRUITING

    Valencia, Valencia, 46026, Spain