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Could taking chantix for a month before quitting boost success rates?

NCT ID NCT03262662

Completed Disease control Sponsor: State University of New York at Buffalo Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested whether taking varenicline (Chantix) for four weeks before quitting smoking, instead of the standard one week, helps more people stay smoke-free. 320 smokers were randomly assigned to either the extended or standard pre-quit schedule, along with counseling. The main goal was to see if the longer run-in led to higher rates of continuous abstinence at the end of treatment and at six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
varenicline (Chantix) and brief smoking cessation counseling
What this could lead to
If successful, this could make the best available smoking cessation treatment even more effective by reducing the urge to smoke before quitting, leading to higher long-term quit rates.
What could go wrong
This is a completed Phase 3 trial, but results may not apply to all smokers. Varenicline can cause side effects like nausea, sleep problems, and mood changes. The extended pre-quit period may not improve outcomes for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Tobacco Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TOBACCO SMOKING

Contacts and locations

Locations

  • State University of New York at Buffalo

    Buffalo, New York, 14260, United States

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