New hope for myeloma patients who Can't have transplants

NCT ID NCT07095452

Recruiting now Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental drug called etentamig combined with daratumumab in people newly diagnosed with multiple myeloma who are not eligible for a stem cell transplant. About 660 participants will receive either the new combination or standard treatment. The goal is to see if the new combo improves response rates and delays disease progression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Etentamig (an investigational drug) combined with daratumumab
What this could lead to: If successful, this could offer a new treatment option for people with newly diagnosed multiple myeloma who cannot have a stem cell transplant, potentially improving disease control and survival.
What could go wrong: This is an early-to-mid-stage trial, so the experimental drug may not work better than current treatments or could cause unexpected side effects. Results may take years to confirm.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Locations

Blue Ridge Cancer Care - Roanoke /ID# 278722
RECRUITING

Roanoke, Virginia, 24014, United States
CH Bretagne Atlantique /ID# 278422
RECRUITING

Vannes, Morbihan, 56000, France
CHRU Tours - Hopital Bretonneau /ID# 279274
RECRUITING

Tours, Indre-et-Loire, 37044, France
CHU de Montpellier - Hopital Saint Eloi /ID# 278415
RECRUITING

Montpellier, Herault, 34295, France
Cedars-Sinai Medical Center /ID# 278238
RECRUITING

Los Angeles, California, 90048, United States
Centre Hospitalier Annecy Genevois /ID# 278406
RECRUITING

Epagny Metz Tessy, Auvergne-Rhône-Alpes, 74370, France
Centre Hospitalier De Dunkerque-Hospital Alexandra Lepeve /ID# 278399
RECRUITING

Dunkirk, Hauts-de-France, 59385, France
Centre Hospitalier Universitaire de Bordeaux /ID# 278419
RECRUITING

Pessac, New Aquitaine, 33604, France
Centre Hospitalier Universitaire de Nantes, Hotel Dieu -HME /ID# 278402
RECRUITING

Nantes, Pays de la Loire Region, 44000, France
Centre Hospitalier Universitaire de Poitiers /ID# 278398
RECRUITING

Poitiers, New Aquitaine, 86021, France
Centre Hospitalier Universitaire de Saint Etienne - Hopital Nord /ID# 278421
RECRUITING

St-Priest-en-Jarez, Pays de la Loire Region, 42270, France
Chu De Lille - Hopital Claude Huriez /ID# 278413
RECRUITING

Lille, Hauts-de-France, 59037, France
Clinica Universidad de Navarra - Pamplona /ID# 278583
RECRUITING

Pamplona, Navarre, 31008, Spain
Colorado Blood Cancer Institute /ID# 279080
RECRUITING

Denver, Colorado, 80218, United States
Complejo Asistencial Universitario de Leon - Hospital de Leon /ID# 278534
RECRUITING

León, 24071, Spain
Complejo Hospitalario Universitario de Santiago /ID# 278531
RECRUITING

Santiago de Compostela, A Coruna, 15706, Spain
Fort Wayne Medical Oncology And Hematology /ID# 278141
RECRUITING

Fort Wayne, Indiana, 46804, United States
HCL - Hopital Lyon Sud /ID# 282145
RECRUITING

Pierre-Bénite, Rhone, 69495, France
Hopital Saint Antoine /ID# 278428
RECRUITING

Paris, 75012, France
Hopital Saint-Louis /ID# 278429
RECRUITING

Paris, 75010, France
Hopital Universitaire Necker Enfants Malades /ID# 278426
RECRUITING

Paris, Île-de-France Region, 75015, France
Hospital Clinic de Barcelona /ID# 278532
RECRUITING

Barcelona, 08036, Spain
Hospital General Universitario Gregorio Maranon /ID# 278551
RECRUITING

Madrid, 28007, Spain
Hospital Universitari i Politecnic La Fe /ID# 278525
RECRUITING

Valencia, 46026, Spain
Hospital Universitario 12 de Octubre /ID# 278520
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Marques de Valdecilla /ID# 278535
RECRUITING

Santander, Cantabria, 39008, Spain
Hospital Universitario Ramon y Cajal /ID# 278533
RECRUITING

Madrid, 28034, Spain
Hospital Universitario de Gran Canaria Doctor Negrín /ID# 278527
RECRUITING

Las Palmas de Gran Canaria, Las Palmas, 35010, Spain
Hospital Universitario de Salamanca /ID# 278530
RECRUITING

Salamanca, 37007, Spain
IUCT Oncopole /ID# 278403
RECRUITING

Toulouse, Occitanie, 31059, France
Icahn School of Medicine at Mount Sinai /ID# 277844
RECRUITING

New York, New York, 10029, United States
Institut Catala d'Oncologia (ICO) - Badalona /ID# 278522
RECRUITING

Badalona, Barcelona, 08916, Spain
Kurume University Hospital /ID# 278209
RECRUITING

Kurume-shi, Fukuoka, 830-0011, Japan
Matsuyama Red Cross Hospital /ID# 278660
RECRUITING

Matsuyama, Ehime, 790-8524, Japan
Mayo Clinic Hospital Rochester /ID# 277886
RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic Hospital Scottsdale /ID# 278349
RECRUITING

Scottsdale, Arizona, 85259, United States
Memorial Sloan Kettering Cancer Center - New York - York Avenue /ID# 277946
RECRUITING

New York, New York, 10065, United States
Minnesota Oncology - Minneapolis Clinic /ID# 278720
RECRUITING

Minneapolis, Minnesota, 55404, United States
Nagoya City University Hospital /ID# 278188
RECRUITING

Nagoya, Aichi-ken, 467-8602, Japan
SCRI Oncology Partners /ID# 278353
RECRUITING

Nashville, Tennessee, 37203, United States
Texas Oncology - Northeast Texas /ID# 278725
RECRUITING

Tyler, Texas, 75702, United States
Texas Oncology - The Woodlands /ID# 278726
RECRUITING

The Woodlands, Texas, 77380, United States
Tokai University Hospital /ID# 278157
RECRUITING

Isehara, Kanagawa, 259-1193, Japan
University Hospital Kyoto Prefectural University of Medicine /ID# 278156
RECRUITING

Kyoto, Kyoto, 602-8566, Japan
University of North Carolina at Chapel Hill /ID# 277708
RECRUITING

Chapel Hill, North Carolina, 27514, United States
Virginia Cancer Specialists - Fairfax /ID# 278716
RECRUITING

Fairfax, Virginia, 22031, United States
Weill Cornell Medicine Myeloma Center /ID# 278216
RECRUITING

New York, New York, 10065, United States
Willamette Valley Cancer Institute and Research Center /ID# 278721
RECRUITING

Eugene, Oregon, 97401, United States
Winship Cancer Institute of Emory University /ID# 277667
RECRUITING

Atlanta, Georgia, 30322, United States

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