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Blood test for biological age may reveal who will succeed at IVF

NCT ID NCT07875140

Knowledge-focused Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Oct 15, 2026 · Last updated Oct 16, 2026 · Updated 1 time

Summary

Researchers are studying whether a blood test that estimates biological age from DNA can predict which women undergoing IVF or ICSI will have a live birth. The study enrolls 400 women and compares the test results between those who achieve a live birth and those who do not. A smaller group of 30 women under 40 also gives blood before and after ovarian stimulation to see if the test result changes. The extra blood is taken during routine draws, so participation does not change clinical care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a blood test that estimates biological age from DNA methylation
What this could lead to
If the test proves accurate, doctors could one day use a routine blood draw to estimate a woman's chances of a live birth through IVF and tailor treatment advice.
What could go wrong
This is an observational study, so it can only show links, not cause and effect. The biological age test is not yet validated for fertility, and results may not hold across different groups of women.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

400 people

The number who actually took part.

Started

Mar 2025

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult women undergoing IVF or ICSI at two Italian assisted reproduction centers.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years or older * Indication for IVF or ICSI * FSH levels below 15 IU/mL * Signed informed consent Exclusion Criteria: * Uterine abnormalities (fibroids, adenomyosis, endometrial polyps, uterine septum) * Hydrosalpinx diagnosed on baseline ultrasound * Severe male factor infertility (azoospermia with surgical sperm retrieval, cryptozoospermia, necrozoospermia) * Systemic diseases that may negatively affect pregnancy and cause miscarriage (e.g., diabetes, uncompensated thyroid disease, antiphospholipid syndrome) Additional blood sampling subgroup: the first 30 enrolled women under 40 years of age who agreed to participate through a specific consent.

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Conditions

The condition(s) this trial relates to.

female infertility infertility disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infertility assisted reproductive technology Ovarian aging

Contacts and locations

Locations

  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

    Milan, Italy

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