Could a simple additive to epidurals prevent chronic pain after surgery?

NCT ID NCT07292324

Completed Symptom relief Sponsor: Udayana University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether adding dexmedetomidine to a standard epidural painkiller (bupivacaine) improves pain control for women undergoing gynecologic laparotomy. 62 women received either the standard epidural or one with dexmedetomidine added. Researchers measured pain levels, painkiller use, and inflammation markers for 24 hours after surgery, and checked for chronic pain 3 months later.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Dexmedetomidine (added to bupivacaine epidural)
What this could lead to: If it works, this could offer better short-term pain relief and lower the chance of long-term pain after gynecologic surgery.
What could go wrong: This is a small, completed Phase 4 trial with 62 participants, so results may not apply to everyone. Adding dexmedetomidine may cause side effects like low blood pressure or slow heart rate.

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Conditions

The condition(s) this trial relates to.

female reproductive system disorder Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC POST-SURGICAL PAIN GYNECOLOGIC DISEASE POST OPERATIVE PAIN, ACUTE

Contacts and locations

Locations

Prof. Dr. I.G.N.G Ngoerah Central General Hospital

Denpasar, Bali, 80114, Indonesia

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