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Can a common blood pressure drug make anesthesia safer for the very old?

NCT ID NCT06681662

Symptom relief Sponsor: Matias Vested Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 11, 2026 · Last updated Sep 11, 2026

Summary

Researchers are testing whether giving ephedrine before the muscle relaxant rocuronium helps the drug work faster in patients aged 80 and older who are having surgery with general anesthesia and a breathing tube. The trial compares ephedrine to a saline placebo in 80 patients. The goal is to see if ephedrine shortens the time until muscles are fully relaxed, which could make intubation quicker and easier.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ephedrine, a drug that raises blood pressure and heart rate, given before the muscle relaxant rocuronium
What this could lead to
If it works, this could give anesthesiologists a simple way to speed up muscle relaxation for older patients, potentially making intubation faster and safer.
What could go wrong
The trial is small and only in people aged 80 and older, so results may not apply to other groups. Ephedrine can raise heart rate and blood pressure, which may be risky for some patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

80 people

The number who actually took part.

Started

Jan 2025

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

80 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 80 * Scheduled for elective operations under general anesthesia with intubation * American Society of Anesthesiologists physical status classification (ASA) I to III * Informed consent * Read and understand Danish Exclusion Criteria: * Known allergy to rocuronium or ephedrine * Neuromuscular disease that may interfere with neuromuscular data * Indication for rapid sequence induction * Daily use of beta-blocking agents * Known cardiac arrythmia (atrial fibrillation, supraventricular or ventricular)

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Neuromuscular blockade

Contacts and locations

Locations

  • Department of Anaesthesiology, Pain and Respiratory Support, Rigshospitalet Glostrup

    Copenhagen, 2100, Denmark

  • Department of Anesthesia, Centre of Head and Orthopedics, 6013 Rigshospitalet

    Copenhagen, 2100, Denmark

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