New drug cocktail targets Hard-to-Treat lymphoma

NCT ID NCT05283720

Ongoing Disease control Sponsor: Genmab Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 08, 2026 · Updated 3 times

Summary

This study tests an experimental drug called epcoritamab given together with other anti-cancer medicines in adults with Non-Hodgkin lymphoma (NHL), a type of blood cancer. About 496 participants will receive different combinations depending on their lymphoma subtype and treatment history. The main goal is to check safety and how well the tumors respond.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Epcoritamab (an investigational antibody) combined with other anti-cancer drugs
What this could lead to: If successful, this could offer new combination treatment options for people with certain types of Non-Hodgkin lymphoma that are hard to treat.
What could go wrong: This is an early-phase trial (Phase 1b/2) testing many different drug combinations, so results may not lead to a standard treatment. Side effects from combining multiple anti-cancer drugs could be significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma follicular lymphoma hairy cell leukemia mantle cell lymphoma neoplasm non-Hodgkin lymphoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-HODGKIN LYMPHOMA

Contacts and locations

Locations

Aalborg University Hospital /ID# 242734

Aalborg, North Denmark, 9000, Denmark
Aarhus Universitetshospital - Skejby /ID# 242670

Aarhus, Central Jutland, 8200, Denmark
Alliance for Multispecialty Research (AMR) - Kansas City /ID# 242144

Kansas City, Missouri, 64114-4859, United States
Asan Medical Center /ID# 242400

Seoul, Seoul Teugbyeolsi, 05505, South Korea
Beijing Cancer Hospital /ID# 252303

Beijing, Beijing Municipality, 100142, China
CHRU Lille - Hopital Claude Huriez /ID# 242335

Lille, Nord, 59037, France
CHU Clermont-Ferrand /ID# 242344

Clermont, Auvergne-Rhône-Alpes, 63100, France
CHU de Rennes - PONTCHAILLOU /ID# 242339

Rennes, Brittany Region, 35000, France
CLINICA UNIVERSIDAD DE NAVARRA-Madrid /ID# 243268

Madrid, 28027, Spain
Centre Hospitalier Regional Universitaire de Nancy - Hopitaux de Brabois /ID# 242342

Vandœuvre-lès-Nancy, Meurthe-et-Moselle, 54511, France
Centre Hospitalier Universitaire de Nantes, Hotel Dieu -HME /ID# 242345

Nantes, Pays de la Loire Region, 44000, France
China Medical University Hospital /ID# 242893

Taichung, 40447, Taiwan
Christiana Care Health Service /ID# 242301

Newark, Delaware, 19713, United States
Clinica Universidad de Navarra - Pamplona /ID# 245031

Pamplona, Navarre, 31008, Spain
Debreceni Egyetem-Klinikai Kozpont /ID# 242450

Debrecen, Hajdú-Bihar, 4032, Hungary
Duplicate_Erasmus Medisch Centrum /ID# 243315

Rotterdam, South Holland, 3015 GD, Netherlands
East Carolina University - Brody School of Medicine /ID# 242506

Greenville, North Carolina, 27834, United States
Fakultni Nemocnice Brno - Jihlavska /ID# 242683

Brno, Brno-mesto, 625 00, Czechia
Fakultni Nemocnice Ostrava /ID# 242684

Ostrava, Ostrava-mesto, 708 52, Czechia
Fakultni nemocnice Hradec Kralove - Sokolska /ID# 241722

Hradec Králové, 500 05, Czechia
Fox Chase Cancer Center /ID# 242106

Philadelphia, Pennsylvania, 19111, United States
Fudan University Shanghai Cancer Center /ID# 252292

Shanghai, Shanghai Municipality, 200032, China
HCL - Hopital Lyon Sud /ID# 242349

Pierre-Bénite, Rhone, 69495, France
Hadassah Medical Center-Hebrew University /ID# 243013

Jerusalem, Jerusalem, 91120, Israel
Hokkaido University Hospital /ID# 248999

Sapporo, Hokkaido, 060-8648, Japan
Hopital Pitie Salpetriere /ID# 242343

Paris, Île-de-France Region, 75013, France
Hopital Saint-Louis /ID# 242336

Paris, 75010, France
Hopitaux Universitaires Henri Mondor - Hopital Henri Mondor /ID# 242337

Créteil, Paris, 94010, France
Hospital Clinico Universitario de Valencia /ID# 243269

Valencia, 46010, Spain
Hospital Universitario 12 de Octubre /ID# 243262

Madrid, 28041, Spain
Hospital Universitario Fundacion Jimenez Diaz /ID# 243264

Madrid, 28040, Spain
Hospital Universitario Vall de Hebron /ID# 243260

Barcelona, 08035, Spain
Hospital Universitario Virgen del Rocio /ID# 243267

Seville, 41013, Spain
Hospital Universitario de Salamanca /ID# 243368

Salamanca, 37711, Spain
IUCT Oncopole /ID# 242340

Toulouse, Occitanie, 31059, France
Icahn School of Medicine at Mount Sinai /ID# 242123

New York, New York, 10029, United States
Institut Catala dOncologia - LHospitalet /ID# 243261

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Instituto Catalan de Oncologia (ICO) Badalona /ID# 243265

Badalona, Barcelona, 08916, Spain
Joe Arrington Cancer Research /ID# 242226

Lubbock, Texas, 79410, United States
Klinikum Augsburg /ID# 244523

Augsburg, Bavaria, 86156, Germany
Kyoto University Hospital /ID# 248997

Kyoto, Kyoto, 606-8507, Japan
Leids Universitair Medisch Centrum /ID# 243316

Leiden, South Holland, 2333 ZA, Netherlands
Maastricht Universitair Medisch Centrum /ID# 243317

Maastricht, Limburg, 6229 HX, Netherlands
MultiCare Institute for Research and Innovation /ID# 242127

Tacoma, Washington, 98405, United States
National Cancer Center Hospital /ID# 248995

Chuo-ku, Tokyo, 104-0045, Japan
National Cheng Kung University Hospital /ID# 242894

Tainan, 704, Taiwan
Northwell Health - Monter Cancer Center /ID# 245435

Lake Success, New York, 11042, United States
Novant Health Forsyth Medical Center /ID# 242198

Winston-Salem, North Carolina, 27103, United States
Novant Health Presbyterian Medical Center /ID# 242148

Charlotte, North Carolina, 28204, United States
Orszagos Onkologiai Intezet /ID# 242458

Budapest, 1122, Hungary
Rabin Medical Center. /ID# 243014

Petah Tikva, Central District, 4941492, Israel
Samsung Medical Center /ID# 242401

Seoul, Seoul Teugbyeolsi, 06351, South Korea
Semmelweis Egyetem /ID# 242454

Budapest, 1085, Hungary
Seoul National University Bundang Hospital /ID# 242404

Seongnam-si, Gyeonggido, 13620, South Korea
Seoul National University Hospital /ID# 242402

Seoul, Seoul Teugbyeolsi, 03080, South Korea
Somogy Varmegyei Kaposi Mor Oktato Korhaz /ID# 245935

Kaposvár, Somogy County, 7400, Hungary
Swedish Medical Center - Seattle /ID# 242269

Seattle, Washington, 98104, United States
Taipei Veterans General Hosp /ID# 242892

Taipei, 11217, Taiwan
Tampa General Hospital /ID# 246748

Tampa, Florida, 33606, United States
Tel Aviv Sourasky Medical Center /ID# 243012

Tel Aviv, Tel Aviv, 6423906, Israel
The Catholic University of Korea, Seoul St. Marys Hospital /ID# 242403

Seoul, Seoul Teugbyeolsi, 06591, South Korea
The Chaim Sheba Medical Center /ID# 243010

Ramat Gan, Tel Aviv, 5265601, Israel
The University of Arizona Cancer Center - North Campus /ID# 242219

Tucson, Arizona, 85719, United States
Thomas Jefferson University Hospital /ID# 242077

Philadelphia, Pennsylvania, 19107, United States
Thompson Cancer Survival Ctr /ID# 242150

Knoxville, Tennessee, 37916, United States
Universitaetsklinikum Giessen und Marburg /ID# 245308

Marburg, Hesse, 35043, Germany
Universitaetsklinikum Leipzig /ID# 245513

Leipzig, Saxony, 04103, Germany
Universitaetsklinikum Regensburg /ID# 244517

Regensburg, Bavaria, 93042, Germany
Universitaetsklinikum Ulm /ID# 244265

Ulm, Baden-Wurttemberg, 89081, Germany
Universitaetsklinikum Wuerzburg /ID# 245453

Würzburg, Bavaria, 97080, Germany
Universitair Medisch Centrum Groningen /ID# 243318

Groningen, 9713 GZ, Netherlands
University of Maryland, Baltimore /ID# 242218

Baltimore, Maryland, 21201, United States
Vrije Universiteit Medisch Centrum /ID# 243319

Amsterdam, North Holland, 1081 HV, Netherlands
Vseobecna Fakultni nemocnice v Praze /ID# 242685

Prague, Praha 17, 128 00, Czechia
Winship Cancer Institute of Emory University /ID# 242153

Atlanta, Georgia, 30322, United States
Yale University School of Medicine /ID# 242089

New Haven, Connecticut, 06510, United States

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