New daily pill could help kids with inherited high cholesterol

NCT ID NCT07058077

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 6 times

Summary

This study tests a daily pill called enlicitide decanoate in 153 children and teens with heterozygous familial hypercholesterolemia (HeFH), a genetic condition causing very high cholesterol. The goal is to see if the drug safely lowers LDL cholesterol more than a placebo. Researchers will also check how the drug moves through the body and any side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: enlicitide decanoate (a daily pill to lower cholesterol)
What this could lead to: If it works, this could give children with inherited high cholesterol a new daily pill option to lower their cholesterol and reduce heart risks.
What could go wrong: This is an early-to-mid stage study with only 153 children, so results may not confirm long-term safety or effectiveness. Side effects are possible, and the drug may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

familial hypercholesterolemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (HEFH)

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Amsterdam UMC, locatie AMC ( Site 1000)
RECRUITING

Amsterdam, North Holland, 1105 AZ, Netherlands
Beijing Anzhen Hospital. Capital Medical University ( Site 1917)
RECRUITING

Beijing, Beijing Municipality, 100029, China
Birmingham Childrens Hospital ( Site 1501)
RECRUITING

Birmingham, B4 6NH, United Kingdom
Boston Children's Hospital ( Site 0018)
RECRUITING

Boston, Massachusetts, 02115, United States
COMPLEJO HOSPITALARIO DE NAVARRA ( Site 1302)
RECRUITING

Pamplona, Navarre, 31009, Spain
Centro de Investigacion Clinica de Oaxaca ( Site 0505)
RECRUITING

Oaxaca City, Oaxaca, 68020, Mexico
Children's Healthcare of Atlanta Cardiology ( Site 0026)
RECRUITING

Atlanta, Georgia, 30329, United States
Children's Hospital Capital Institute of Pediatrics ( Site 1908)
RECRUITING

Beijing, Beijing Municipality, 100020, China
Children's Hospital of Fudan University ( Site 1906)
RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Children's National Medical Center ( Site 0015)
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Cincinnati Children's Hospital Medical Center ( Site 0016)
RECRUITING

Cincinnati, Ohio, 45229, United States
Clinica de la Costa S.A.S. ( Site 0400)
RECRUITING

Barranquilla, Atlántico, 080020, Colombia
Detska nemocnice FN Brno ( Site 0701)
RECRUITING

Brno, Brno-mesto, 613 00, Czechia
Excel Medical Clinical Trials ( Site 0008)
RECRUITING

Boca Raton, Florida, 33434, United States
Explora Salud ( Site 0304)
RECRUITING

Santiago, Region M. de Santiago, 7500504, Chile
Fakultni nemocnice v Motole ( Site 0700)
RECRUITING

Prague, 150 00, Czechia
Fundacion Valle del Lili ( Site 0403)
RECRUITING

Cali, Valle del Cauca Department, 760032, Colombia
Fundación Cardiovascular de Colombia ( Site 0402)
RECRUITING

Piedecuesta, Santander Department, 681017, Colombia
Guangdong Provincial People's Hospital ( Site 1915)
RECRUITING

Guangzhou, Guangdong, 510080, China
Hospital Clinico Universitario de Santiago de Compostela ( Site 1300)
RECRUITING

Santiago de Compostela, La Coruna, 15706, Spain
Hospital Universitario Central de Asturias ( Site 1303)
RECRUITING

Oviedo, Asturias, Principado de, 33011, Spain
INVECORDIS S.C. ( Site 0503)
RECRUITING

Huixquilucan, 52763, Mexico
Incor - Instituto do Coracao ( Site 0200)
RECRUITING

São Paulo, 05403900, Brazil
Instituto Dante Pazzanese de Cardiology ( Site 0206)
RECRUITING

São Paulo, 04012-909, Brazil
Laboratorio de Patología Clínica del Hospital Universitario "Dr. José Eleuterio González" ( Site 0501)
RECRUITING

Monterrey, Nuevo León, 64460, Mexico
Monash Children s Hospital ( Site 1603)
RECRUITING

Clayton, Victoria, 3168, Australia
National University Hospital-Paediatrics ( Site 1800)
RECRUITING

Singapore, Central Singapore, 117599, Singapore
Nemours/Alfred I. duPont Hospital for Children ( Site 0001)
RECRUITING

Wilmington, Delaware, 19803, United States
New Childrens Hospital ( Site 0800)
RECRUITING

Helsinki, Uusimaa, 00029, Finland
New Zealand Clinical Research (Christchurch) ( Site 1700)
RECRUITING

Christchurch, Canterbury, 8011, New Zealand
Oncomédica S.A.S ( Site 0401)
RECRUITING

Montería, Departamento de Córdoba, 230002, Colombia
Pontificia Universidad Catolica de Chile ( Site 0300)
RECRUITING

Santiago, Region M. de Santiago, 8330032, Chile
Shanghai Children's Medical Center ( Site 1918)
RECRUITING

Shanghai, Shanghai Municipality, 200120, China
Sheffield Childrens Hospital ( Site 1503)
RECRUITING

Sheffield, S10 2TH, United Kingdom
Southampton General Hospital ( Site 1502)
RECRUITING

Southampton, SO16 6YD, United Kingdom
The Children's Hospital of Zhejiang University School of Medicine ( Site 1905)
RECRUITING

Hangzhou, Zhejiang, 310057, China
UZ Antwerpen ( Site 0601)
RECRUITING

Edegem, Antwerpen, 2650, Belgium
Universidade Federal Do Ceara ( Site 0201)
RECRUITING

Fortaleza, Ceará, 60430270, Brazil
Universitaetsklinikum Freiburg ( Site 2203)
RECRUITING

Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
West Virginia University ( Site 0013)
RECRUITING

Morgantown, West Virginia, 26506, United States

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