Gene mutations may explain why some endometriosis treatments fail

NCT ID NCT03756480

First seen Jun 18, 2026 ยท Last updated Jun 18, 2026

Summary

This study looks at whether certain genetic changes (mutations) in endometriosis tissue are linked to resistance to progesterone therapy. Researchers will compare tissue samples from 135 women with and without endometriosis. The goal is to better understand why some cases don't respond to hormone treatment, which could lead to more personalized care.

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Contacts and locations

Locations

  • Johns Hopkins Hospital

    Baltimore, Maryland, 21218, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, 37232, United States

  • Yale School of Medicine

    New Haven, Connecticut, 06510, United States

Conditions

The condition(s) this trial relates to.

endometrial disorder endometriosis uterine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.