Gene mutations may explain why some endometriosis treatments fail

NCT ID NCT03756480

Ongoing Knowledge-focused Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether certain genetic changes (mutations) in endometriosis tissue are linked to resistance to progesterone therapy. Researchers will compare tissue samples from 135 women with and without endometriosis. The goal is to better understand why some cases don't respond to hormone treatment, which could lead to more personalized care.

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Conditions

The condition(s) this trial relates to.

endometrial disorder endometriosis uterine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIAL DISEASES ENDOMETRIOSIS

Contacts and locations

Locations

Johns Hopkins Hospital

Baltimore, Maryland, 21218, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Yale School of Medicine

New Haven, Connecticut, 06510, United States

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