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Can a diabetes drug shield kidney cells in Non-Diabetic kidney disease?

NCT ID NCT06110130

Disease control Sponsor: Washington D.C. Veterans Affairs Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 21, 2026 · Last updated Aug 21, 2026

Summary

This trial tests whether empagliflozin, a drug already used for diabetes, can protect kidney cells in African American veterans who have chronic kidney disease but do not have diabetes. Participants will take either empagliflozin or a placebo daily for four months. Researchers will measure specific proteins in urine that signal kidney cell injury, and see if the drug reduces these markers and improves kidney function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
empagliflozin 10 mg taken by mouth daily for 4 months
What this could lead to
If it works, empagliflozin could offer a new way to slow kidney damage in people with non-diabetic chronic kidney disease, particularly in African American veterans.
What could go wrong
This is a small, early-stage trial with only 60 participants, so results may not apply broadly. The drug may not show a clear benefit on the measured markers, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2024

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. African American veterans 2. Age \> 18 years 3. eGFR ≥20-59 mL/min/1.73 m2 by the CKD-EPI equation, with or without any degree of albuminuria OR 4. eGFR 60-89, with UACR of ≥30mg/g 5. BMI = 18-39.9 6. Blood pressure controlled to ≤140/90 7. Subjects without diabetes: will be screened using routine glucose level test: of less than 126 fasting glucose or less than 200mg/dl of random or post glucose blood glucose level in standard of care laboratory workup. 8. Ability to provide informed consent before any trial related activities are conducted. Exclusion Criteria: 1. Diagnosed with Type 1 or Type 2 Diabetes Mellitus 2. Any prescribed diabetes medication for patients, such as GLP1RA, SGLT2is, and sulphonylureas 3. If a patient is on statin, need to be on a stable dose for a month. 4. Biopsy proven diagnosis of glomerular disease/glomerulonephritis 5. Active smokers, 6. Active skin wounds undergoing treatment or recent surgery within 1 month (due to possible aberrations in glycemic control) 7. Women who are pregnant, planning to become pregnant, nursing mothers, women of childbearing potential not using birth control measure 8. Hypersensitivity to empagliflozin or any of the excipients in Jardiance, reactions such as angioedema 9. Patients on dialysis 10. eGFR less than 20 mL/min/1.73 m2 by the CKD-EPI equation 11. Planned surgery or planned hospital admission within 5 months of participation in the study 12. At the discretion of PI to ensure health, safety, and well-being of the veteran, participation in this study may be stopped (please see withdrawal criteria) 13. Patients with prior history of diagnosis of heart failure with documented EF of less than 50. 14. Proven diagnosis of Polycystic Kidney Disease.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic kidney diseases

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Washington DC Veterans Affairs Medical Center (688)

    RECRUITING

    Washington D.C., District of Columbia, 20422, United States

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