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Eggs vs. pills: which choline source is safer for your heart?

NCT ID NCT03039023

Completed Knowledge-focused Sponsor: The Cleveland Clinic Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 14, 2026 · Updated 3 times

Summary

This study looked at how choline from eggs or supplements affects levels of TMAO, a compound linked to higher heart disease risk. Researchers gave 86 healthy adults either whole eggs, egg whites, choline supplements, or phosphatidylcholine capsules for 28 days. The goal was to see if the source of choline changes TMAO levels differently.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Choline (from eggs or supplements)
What this could lead to
If successful, this study could clarify whether dietary sources of choline (like eggs) are safer than supplements regarding heart disease risk.
What could go wrong
This is a small, completed observational study, not a treatment trial. Results may not apply to everyone, and it does not test any new therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR RISK FACTOR

Contacts and locations

Locations

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

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