Breakthrough trial aims to stop devastating genetic disease before it starts

NCT ID NCT06563895

Recruiting now Prevention Sponsor: Eidos Therapeutics, a BridgeBio company Source: ClinicalTrials.gov ↗

Summary

This study is testing whether a new drug called acoramidis can prevent or delay heart and nerve damage in people who carry a gene for a serious disease but don't yet have symptoms. About 582 adults aged 18-75 with the genetic risk will receive either the drug or a placebo to see if early treatment stops the disease from developing. The goal is to see if stabilizing a faulty protein in the blood can prevent harmful plaque from building up in organs.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AP-HP Hopital Bicetre
RECRUITING

Le Kremlin-Bicêtre, 94270, France
AP-HP Hopital Henri Mondor
RECRUITING

Créteil, 94000, France
Azienda Ospedaliero-Universitaria Careggi
RECRUITING

Florence, Italy
Azienda Ospedaliero-Universitaria Sant'Andrea
RECRUITING

Rome, 00189, Italy
Azienda Ospedaliero-Universitaria di Bologna IRCCS Policlinico di S.Orsola
RECRUITING

Bologna, 40138, Italy
Boston University (BU) School of Medicine
RECRUITING

Boston, Massachusetts, 02118, United States
Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
CAPED - Centro Avancado de Pesquisa, Estudos e Diagnostico
RECRUITING

Ribeirão Preto, 14026-900, Brazil
CHU Bordeaux - Hopital Pellegrin
RECRUITING

Bordeaux, 33076, France
CHU Rennes
RECRUITING

Rennes, 35000, France
CHU de Fort de France
RECRUITING

Fort-de-France, 97261, Martinique
CHU de Toulouse - Hopital Rangueil
RECRUITING

Toulouse, 31400, France
Cardiopulmonar da Bahia S.A. (Hospital Cardio Pulmonar)
RECRUITING

Salvador, 40170-130, Brazil
Changhua Christian Hospital - Taiwan
RECRUITING

Changhua, 500, Taiwan
Charite Universitaetsmedizin Berlin
RECRUITING

Berlin, 10117, Germany
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Emory University School of Medicine
RECRUITING

Atlanta, Georgia, 30322, United States
Erasmus MC
RECRUITING

Rotterdam, 3015 GD, Netherlands
Fondazione IRCCS Policlinico San Matteo
RECRUITING

Pavia, 27100, Italy
Fondazione Policlinico Universitario A. Gemelli IRCCS - Universita Cattolica del Sacro Cuore
RECRUITING

Rome, 00168, Italy
Fondazione Toscana Gabriele Monasterio per la Ricerca Medica e di Sanità Pubblica - Ospedale San Cataldo
RECRUITING

Pisa, 56124, Italy
Fundacao Centro Medico de Campinas
RECRUITING

Campinas, 13083-190, Brazil
General Hospital of Athens - Alexandra
RECRUITING

Athens, 11528, Greece
Henry Ford Health System
RECRUITING

Detroit, Michigan, 48202, United States
Hippokration General Hospital of Athens
RECRUITING

Athens, 11527, Greece
Hospital Britanico de Buenos Aires
RECRUITING

Buenos Aires, C1280AEB, Argentina
Hospital Clinico Universitario de Salamanca
RECRUITING

Salamanca, 37007, Spain
Hospital Italiano de Buenos Aires
RECRUITING

Buenos Aires, C1199ABB, Argentina
Hospital Universitari de Bellvitge
RECRUITING

Barcelona, 08907, Spain
Hospital Universitario Juan Ramon Jimenez
RECRUITING

Huelva, Spain
Hospital Universitario Puerta de Hierro
RECRUITING

Majadahonda, Spain
Hospital Universitario Son Llatzer
RECRUITING

Palma de Mallorca, 07198, Spain
Hvitfeldt Poulsen
RECRUITING

Aarhus, 8200, Denmark
INOVA Fairfax Hospital
RECRUITING

Falls Church, Virginia, 22042, United States
Instituto do Coracao (InCor) do Hospital das Clinicas da FMUSP
RECRUITING

Cerqueira César, 05403-000, Brazil
John H. Stroger, Jr. Hospital of Cook County
RECRUITING

Chicago, Illinois, 60612, United States
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21287, United States
Kumamoto University Hospital
RECRUITING

Kumamoto, 860-8556, Japan
Laurelton Heart Specialists
RECRUITING

Rosedale, New York, 11422, United States
Maastricht University Medical Center
RECRUITING

Maastricht, 6229 HX, Netherlands
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic - Jacksonville
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic - Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
MedStar Washington Hospital Center - MedStar Heart and Vascular Institute
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Medical University of South Carolina (MUSC)
RECRUITING

Charleston, South Carolina, 29425, United States
Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
National Institute of Medical Sciences and Nutrition - Salvador Zubiran(INCMNSZ)
RECRUITING

Tlalpan, 14080, Mexico
National Neuromuscular Research Institute
RECRUITING

Austin, Texas, 78759, United States
National Taiwan University Hospital
RECRUITING

Taipei, 10016, Taiwan
New York University (NYU) School of Medicine - Langone Medical Center
RECRUITING

New York, New York, 10016, United States
Norrlands universitetssjukhus (University Hospital of Umea)
RECRUITING

Umeå, 90185, Sweden
Oregon Health & Science University
RECRUITING

Portland, Oregon, 97239, United States
Penn Presbyterian Medical Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Prisma Health Cancer Institute
RECRUITING

Greenville, South Carolina, 89605, United States
Rutgers-Robert Wood Johnson Medical School
RECRUITING

New Brunswick, New Jersey, 08901, United States
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Seoul National University Hospital
RECRUITING

Seoul, 03080, South Korea
Seoul St. Mary's Hospital
RECRUITING

Seoul, 06591, South Korea
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, 03722, South Korea
Shinshu University Hospital
RECRUITING

Nagano, 390-8621, Japan
Singapore General Hospital
RECRUITING

Singapore, 169608, Singapore
St Vincent's Hospital Sydney
RECRUITING

Darlinghurst, 2010, Australia
St. Bartholomew's Hospital
RECRUITING

London, EC1A 7BE, United Kingdom
St. Luke's Hospital of Kansas City
RECRUITING

Kansas City, Missouri, 64111, United States
St. Michael's Hospital
RECRUITING

Toronto, Ontario, M5B1W8, Canada
Stanford University
RECRUITING

Stanford, California, 94305, United States
Taipei Veterans General Hospital
RECRUITING

Taipei, 11217, Taiwan
Tallaght University Hospital - The Adelaide and Meath Hospital
RECRUITING

Dublin, D24 NR04, Ireland
The Mater Misericordiae University Hospital
RECRUITING

Dublin, D07 R2WY, Ireland
UZ Leuven
RECRUITING

Leuven, 3000, Belgium
Unidade Local de Saude de Santa Maria EPE - Hospital de Santa Maria
RECRUITING

Lisbon, 1649-035, Portugal
Unidade Local de Saude de Santo Antonio EPE - Hospital de Santo Antonio
RECRUITING

Porto, 4099-001, Portugal
Universitaetsklinikum Heidelberg
RECRUITING

Heidelberg, 69120, Germany
Universitair Medisch Centrum Utrecht
RECRUITING

Utrecht, 3584 CX, Netherlands
University College London Hospitals NHS Foundation Trust
RECRUITING

London, WC1N 3BG, United Kingdom
University Malaya Medical Centre (UMMC)
RECRUITING

Kuala Lumpur, 59100, Malaysia
University Medical Center Groningen
RECRUITING

Groningen, 9713 GZ, Netherlands
University of British Columbia
RECRUITING

Vancouver, British Columbia, V6Z1Y6, Canada
University of Calgary
RECRUITING

Calgary, Alberta, T2N 4Z6, Canada
University of California, Los Angeles (UCLA) - David Geffen School of Medicine
RECRUITING

Los Angeles, California, 90095, United States
University of California, San Diego (UCSD) - Medical Center
RECRUITING

La Jolla, California, 92037, United States
University of California, San Francisco (UCSF)
RECRUITING

San Francisco, California, 94143, United States
University of Chicago - Medical Center
RECRUITING

Chicago, Illinois, 60637, United States
University of Colorado Anschutz
RECRUITING

Aurora, Colorado, 80045, United States
University of Maryland Medical Center
RECRUITING

Baltimore, Maryland, 21201, United States
University of Pittsburgh Medical Center, Presbyterian Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of Texas Southwestern
RECRUITING

Dallas, Texas, 75390, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84132, United States
Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23219, United States
Washington University in St. Louis
RECRUITING

St Louis, Missouri, 63110, United States
Westmead Hospital
RECRUITING

Westmead, NSW 2145, Australia
Yale University School of Medicine - Section of Cardiology
RECRUITING

New Haven, Connecticut, 06519, United States

Conditions

Explore the condition pages connected to this study.

AMYLOID CARDIOMYOPATHY AMYLOIDOSIS CARDIOMYOPATHIES HEART DISEASES POLYNEUROPATHIES TRANSTHYRETIN AMYLOIDOSIS