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Amino acid supplement and exercise: a recipe for stronger muscles and sharper energy?

NCT ID NCT07792603

Knowledge-focused Sponsor: University of North Carolina, Chapel Hill Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 28, 2026 · Last updated Sep 04, 2026 · Updated 4 times

Summary

Researchers at the University of North Carolina are testing whether a daily essential amino acid supplement, called Daily Upgrade EAA+, combined with twice-weekly high-intensity interval training (HIIT) can improve muscle size, metabolic rate, and energy in healthy women aged 25 to 45. The study has two parts: an acute phase where participants receive the supplement, whey protein, or a placebo before a single HIIT session, and a chronic phase where they take the supplement or placebo for three weeks while doing HIIT. The team measures amino acid levels, fat burning, lean body mass, and muscle size to see if the supplement adds benefits beyond exercise alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
An essential amino acid supplement (Daily Upgrade EAA+) compared with whey protein and placebo, with or without high-intensity interval training
What this could lead to
If it works, this could point toward a simple supplement-plus-exercise routine that helps healthy women improve muscle tone, metabolism, and energy.
What could go wrong
The trial is small and short, so results may not apply broadly. Supplements can cause digestive discomfort, and the benefits may be modest or absent.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 44 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

25 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participant is an adult between the ages of 25-45 years * Participant has a recorded BMI between 18.5-30 kg/m\^2 * Participant is apparently healthy and free from disease, as determined by a health history questionnaire * Participant is a biological female * Participant is naturally menstruating or uses a form of hormonal contraceptive * Participant is recreationally active, based on the International Physical Activity Questionnaire- Short Form * Participant agrees to abstain from caffeine (12 hours), tobacco, alcohol, and exercise for 24 hours prior to testing days * Participant is willing and able to comply with the protocol Exclusion Criteria: * Participant has been diagnosed with chronic heart disease, arrhythmias, thyroid disease, renal, hepatic, autoimmune or neurological diseases, as determined by a health history questionnaire. * Participant has a musculoskeletal disorder or injury that would prohibit them from being able to safely complete the study protocol. * Participant is currently enrolled in a separate clinical trial or weight loss program involving diet, exercise, physical activity, or the potential ingestion of an active drug or dietary supplement * Participant is using, or has consistently used one of the following dietary supplements within 1 month prior to enrollment: whey protein, creatine, essential amino acids * Participant has a known allergy or sensitivity to the placebo or active ingredients * Participant is pregnant or planning to become pregnant * Participant does not speak English or is hearing impaired

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy women

How to take part

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  1. The places running it

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  2. The official record

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Contacts and locations

Locations

  • Applied Physiology Laboratory

    RECRUITING

    Chapel Hill, North Carolina, 27599, United States

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