Can a Lower-Dose botox match the standard for hemifacial spasm?
NCT ID NCT04589364
First seen Aug 17, 2026 · Last updated Aug 17, 2026
Summary
This trial tests whether a lower dose of one botulinum toxin type A (Neuronox) works as well as a higher dose of another (Dysport) for treating hemifacial spasm, a condition causing involuntary facial muscle twitching. About 107 adults with hemifacial spasm will receive both treatments in a random order, with a washout period in between. The study measures how well each injection reduces spasm severity and duration over several weeks, aiming to see if the lower-dose option is non-inferior.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Botulinum toxin type A injections (Dysport or Neuronox)
- What this could lead to
- If successful, this could show that a lower-cost botulinum toxin option works as well as a standard one, offering more choices for treating hemifacial spasm.
- What could go wrong
- This is a phase 3 trial, but results may not apply to all patients. Injections can cause temporary facial weakness or bruising, and the lower dose might be less effective in some people.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Lampang Hospital
Lampang, 52000, Thailand
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Rajavithi Hospital
Bangkok, 10400, Thailand
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Sappasitthiprasong Hospital
Ubon Ratchathani, 34000, Thailand
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Surat Thani hospital
Surat Thani, 84000, Thailand
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