New drug cocktail shows promise for tough liver cancer

NCT ID NCT02519348

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested different combinations of immune-boosting drugs (durvalumab, tremelimumab, and bevacizumab) in 433 adults with advanced liver cancer that had worsened after standard treatment. The goal was to see if these drugs are safe and can shrink tumors or slow the disease. While not a cure, the approach aims to give patients more time and better control over their cancer.

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Research Site

    Phoenix, Arizona, 85054, United States

  • Research Site

    San Francisco, California, 94158, United States

  • Research Site

    New Haven, Connecticut, 06510, United States

  • Research Site

    Jacksonville, Florida, 32224, United States

  • Research Site

    Tampa, Florida, 33612, United States

  • Research Site

    Indianapolis, Indiana, 46202, United States

  • Research Site

    Boston, Massachusetts, 02114, United States

  • Research Site

    New York, New York, 10065, United States

  • Research Site

    Stony Brook, New York, 11794, United States

  • Research Site

    Durham, North Carolina, 27705, United States

  • Research Site

    Portland, Oregon, 97213, United States

  • Research Site

    Philadelphia, Pennsylvania, 19107, United States

  • Research Site

    Philadelphia, Pennsylvania, 19111, United States

  • Research Site

    Nashville, Tennessee, 37203, United States

  • Research Site

    Dallas, Texas, 75390, United States

  • Research Site

    Seattle, Washington, 98109, United States

  • Research Site

    Hangzhou, 310016, China

  • Research Site

    Nanjing, 210002, China

  • Research Site

    Shanghai, 200032, China

  • Research Site

    Hong Kong, Hong Kong

  • Research Site

    Shatin, Hong Kong

  • Research Site

    Benevento, 82100, Italy

  • Research Site

    Milan, 20133, Italy

  • Research Site

    Roma, 00168, Italy

  • Research Site

    Chūōku, 104-0045, Japan

  • Research Site

    Kashiwa, 277-8577, Japan

  • Research Site

    Osakasayama-shi, 589-8511, Japan

  • Research Site

    Bukit Merah, 169610, Singapore

  • Research Site

    Singapore, 119074, Singapore

  • Research Site

    Singapore, 308433, Singapore

  • Research Site

    Busan, 49241, South Korea

  • Research Site

    Junggu, 41944, South Korea

  • Research Site

    Seongnam-si, 13620, South Korea

  • Research Site

    Seoul, 03080, South Korea

  • Research Site

    Seoul, 05505, South Korea

  • Research Site

    Seoul, 06273, South Korea

  • Research Site

    Seoul, 06351, South Korea

  • Research Site

    Barcelona, 08035, Spain

  • Research Site

    Barcelona, 08036, Spain

  • Research Site

    Córdoba, 14004, Spain

  • Research Site

    Pamplona, 31008, Spain

  • Research Site

    Kaohsiung City, 83301, Taiwan

  • Research Site

    Taipei, 100, Taiwan

  • Research Site

    Taoyuan City, 333, Taiwan