New cocktail aims to stall ovarian cancer

NCT ID NCT03737643

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tests whether adding durvalumab (an immunotherapy) and olaparib (a targeted drug) to standard chemotherapy and bevacizumab can help people with newly diagnosed advanced ovarian cancer live longer without their cancer growing. About 1,400 participants are involved. The study compares the new combination against standard treatment alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

durvalumab, bevacizumab, olaparib, carboplatin, paclitaxel

What this could lead to

If successful, this combination could offer a new standard treatment that delays cancer progression in advanced ovarian cancer patients.

What could go wrong

This is a large Phase 3 trial, but results are not yet final. The added drugs may increase side effects without improving outcomes for all patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

fallopian tube cancer ovarian cancer ovarian carcinoma primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED OVARIAN CANCER

Contacts and locations

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Locations

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Foothill Ranch, California, 92610, United States
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Los Angeles, California, 90095, United States
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Orange, California, 92868-3298, United States
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San Francisco, California, 94158, United States
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Tampa, Florida, 33612, United States
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Augusta, Georgia, 30912, United States
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Hinsdale, Illinois, 60521, United States
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Indianapolis, Indiana, 46202, United States
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Towson, Maryland, 21204, United States
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Detroit, Michigan, 48202, United States
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Springfield, Missouri, 65807, United States
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Middletown, New Jersey, 07748, United States
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Montvale, New Jersey, 07645, United States
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Albany, New York, 12208, United States
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New York, New York, 10065, United States
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Uniondale, New York, 11553, United States
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Durham, North Carolina, 27710, United States
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Cleveland, Ohio, 44195, United States
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Dayton, Ohio, 45429, United States
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Hilliard, Ohio, 43026, United States
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Tulsa, Oklahoma, 74134, United States
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Lancaster, Pennsylvania, 17601, United States
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Philadelphia, Pennsylvania, 19104, United States
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Philadelphia, Pennsylvania, 19107-5097, United States
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Pittsburgh, Pennsylvania, 15224, United States
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Salt Lake City, Utah, 84112, United States
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Graz, 8036, Austria
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Innsbruck, 6020, Austria
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Linz, 4020, Austria
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Vienna, 1090, Austria
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Aalst, 9300, Belgium
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Leuven, 3000, Belgium
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Namur, 5000, Belgium
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Ostend, 8400, Belgium
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Sint-Niklaas, 9100, Belgium
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Barretos, 14784-400, Brazil
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Florianópolis, 88034-000, Brazil
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Fortaleza, 60810-180, Brazil
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Londrina, 86015-520, Brazil
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Porto Alegre, 90020-090, Brazil
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Porto Alegre, 90110-270, Brazil
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Rio de Janeiro, 20220-410, Brazil
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São Paulo, 01317-000, Brazil
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São Paulo, 04014-002, Brazil
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Burgas, 8000, Bulgaria
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Plovdiv, 4004, Bulgaria
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Sofia, 1330, Bulgaria
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Varna, 9000, Bulgaria
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Calgary, Alberta, T2N 5G2, Canada
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Barrie, Ontario, L4M 6M2, Canada
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Greater Sudbury, Ontario, P3E 5J1, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Montreal, Quebec, H2X 3E4, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Québec, Quebec, G1J 1Z4, Canada
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Rimouski, Quebec, G5L 5T1, Canada
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Beijing, 100026, China
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Beijing, CN-100730, China
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Bengbu, 233004, China
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Changchun, 130021, China
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Changsha, 410008, China
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Changsha, 430033, China
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Chengdu, 610041, China
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Chongqing, 400030, China
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Dalian, 116001, China
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Guangzhou, 510060, China
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Guangzhou, 510080, China
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Hangzhou, 310009, China
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Hangzhou, 310022, China
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Harbin, 150081, China
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Hefei, 230031, China
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Jinhua, 321099, China
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Kunming, 650118, China
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Lanzhou, 730030, China
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Luzhou, 646099, China
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Nanchong, 637000, China
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Nanjing, 2100008, China
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Nanning, 530021, China
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Nantong, 226361, China
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Shanghai, 200011, China
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Shanghai, 200032, China
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Wuhan, 430030, China
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Wuhan, 430060, China
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Xi'an, 710061, China
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Zhengzhou, 450002, China
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Zhengzhou, 450008, China
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Zhuhai, 519099, China
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Aalborg, 9000, Denmark
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Aarhus N, 8200, Denmark
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Odense, 5000, Denmark
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Roskilde, 4000, Denmark
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Vejle, 7100, Denmark
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Kuopio, 70210, Finland
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Oulu, 90029, Finland
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Turku, 20521, Finland
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Besançon, 25000, France
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Bordeaux, 33076, France
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Limoges, 87042, France
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Lyon, 69373, France
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Marseille, 13273, France
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Nantes, 44202, France
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Paris, 75012, France
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Paris, 75015, France
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Paris, 75674, France
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Saint-Herblain, 44805, France
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Vandœuvre-lès-Nancy, 54519, France
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Bad Homburg, 61352, Germany
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Berlin, 10117, Germany
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Bielefeld, 33604, Germany
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Bonn, 53105, Germany
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Brandenburg, 14770, Germany
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Cologne, 50935, Germany
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Dresden, 1307, Germany
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Düsseldorf, 40489, Germany
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Essen, 45136, Germany
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Essen, 45147, Germany
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Esslingen am Neckar, 73730, Germany
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Frankfurt, 60590, Germany
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Freiburg im Breisgau, 79106, Germany
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Fürth, 90766, Germany
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Greifswald, 17475, Germany
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Gütersloh, 33332, Germany
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Hamburg, 20246, Germany
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Hamburg, 20357, Germany
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Hamburg, 22457, Germany
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Hanover, 30177, Germany
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Hanover, 30625, Germany
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Jena, 07747, Germany
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Karlsruhe, 76133, Germany
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Karlsruhe, 76135, Germany
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Kassel, 34125, Germany
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Kiel, 24105, Germany
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Leipzig, 04103, Germany
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Ludwigsburg, 71640, Germany
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Lübeck, 23538, Germany
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Mainz, 55131, Germany
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Mannheim, 68167, Germany
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München, 81377, Germany
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Offenbach, 63069, Germany
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Oldenburg, 26133, Germany
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Rosenheim, 83022, Germany
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Rostock, 18057, Germany
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Saalfeld, 07318, Germany
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Schweinfurt, 97422, Germany
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Tübingen, 72016, Germany
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Ulm, 89075, Germany
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Worms, 67550, Germany
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Budapest, 1062, Hungary
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Budapest, 1122, Hungary
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Debrecen, 4032, Hungary
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Győr, 9024, Hungary
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Kaposvár, 7400, Hungary
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Szeged, 6725, Hungary
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Zalaegerszeg, 8900, Hungary
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Brescia, 25123, Italy
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Lecce, 73100, Italy
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Lecco, 23900, Italy
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Milan, 20132, Italy
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Milan, 20141, Italy
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Mirano, 30035, Italy
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Naples, 80131, Italy
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Reggio Calabria, 89100, Italy
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Reggio Emilia, 42100, Italy
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Roma, 00168, Italy
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Torino, 10126, Italy
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Torino, 10128, Italy
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Fukuoka, 811-1395, Japan
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Kashiwa-shi, 277-8567, Japan
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Kobe, 650-0047, Japan
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Kōtoku, 135-8550, Japan
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Kurume-shi, 830-0011, Japan
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Kyoto, 606-8507, Japan
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Minatoku, 105-8471, Japan
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Nagoya, 464-8681, Japan
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Niigata, 951-8520, Japan
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Okayama, 700-8558, Japan
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Sapporo, 003-0804, Japan
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Sendai, 980-8574, Japan
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Shinjuku-ku, 160-8582, Japan
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Sunto-gun, 411-8777, Japan
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Toyoake-shi, 470-1192, Japan
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Bellavista, CALLAO 2, Peru
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La Libertad, 13013, Peru
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Lima, LIMA 31, Peru
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Lima, Lima 32, Peru
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Lima, LIMA 34, Peru
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Lima, LIMA 41, Peru
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San Isidro, 27, Peru
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Gdynia, 81-519, Poland
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Lodz, 93-513, Poland
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Szczecin, 70-111, Poland
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Warsaw, 02-781, Poland
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Warsaw, 04-141, Poland
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Floreşti, 407280, Romania
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Goyang-si, 10408, South Korea
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Seongnam-si, 13620, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 06351, South Korea
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Suwon, 16499, South Korea
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Córdoba, 14004, Spain
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Madrid, 28033, Spain
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Madrid, 28034, Spain
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Madrid, 28040, Spain
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Madrid, 28041, Spain
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Terrassa(Barcelona), 08221, Spain
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Vigo, 36312, Spain
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Adana, 1260, Turkey (Türkiye)
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Ankara, 06230, Turkey (Türkiye)
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Ankara, 06490, Turkey (Türkiye)
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Istanbul, 34093, Turkey (Türkiye)
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Istanbul, 34384, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)