Immunotherapy combo shows promise in shrinking lung tumors before surgery
NCT ID NCT05925530
First seen Jun 25, 2026 · Last updated Jul 01, 2026 · Updated 3 times
Summary
This phase 2 trial is testing whether giving the immunotherapy drug durvalumab along with standard chemotherapy before surgery or radiation can help people with stage IIB-IIIB non-small cell lung cancer. The study includes 142 participants whose tumors are considered removable or borderline removable. After initial treatment, some will have surgery followed by more durvalumab, while others will get chemoradiation followed by durvalumab. The main goal is to see how many people can successfully have their tumors surgically removed.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
durvalumab (an immunotherapy drug) plus platinum-based chemotherapy
What this could lead to
If successful, this approach could improve the chances of completely removing lung cancer tumors and help keep the cancer from coming back.
What could go wrong
This is a mid-stage trial with only 142 participants, so results may not apply to everyone. Immunotherapy can cause serious side effects like inflammation of the lungs or other organs.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Research Site
The Bronx, New York, 10467, United States
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Houston, Texas, 77030, United States
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Charlottesville, Virginia, 22908, United States
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Vienna, 1130, Austria
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Vienna, 1140, Austria
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Kingston, Ontario, K7L 2V7, Canada
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Chicoutimi, Quebec, G7H 5H6, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Brno, 625 00, Czechia
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Olomouc, 77900, Czechia
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Prague, 12808, Czechia
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Prague, 150 06, Czechia
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La Tronche, 38700, France
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Marseille, 13008, France
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Montpellier, 34295, France
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Mulhouse, 68070, France
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Paris, 75005, France
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Pessac, 33604, France
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Poitiers, 86000, France
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Toulouse, 31059, France
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Berlin, 13125, Germany
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Cologne, 51109, Germany
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Großhansdorf, 22927, Germany
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Moers, 47441, Germany
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Würzburg, 97074, Germany
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Budapest, 1122, Hungary
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Törökbálint, 2045, Hungary
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Bari, 70124, Italy
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Bologna, 40138, Italy
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Milan, 20132, Italy
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Milan, 20133, Italy
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Milan, 20141, Italy
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Naples, 80131, Italy
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Palermo, 90127, Italy
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Pavia, 27100, Italy
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Peschiera del Garda, 37019, Italy
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Lisbon, 1350-352, Portugal
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Lisbon, 1500-650, Portugal
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Barakaldo, 48903, Spain
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Barcelona, 08025, Spain
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L'Hospitalet de Llobregat, 08908, Spain
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Madrid, 28007, Spain
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Madrid, 28027, Spain
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Madrid, 28046, Spain
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Pamplona, 31008, Spain
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Valencia, 46009, Spain
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Zaragoza, 50009, Spain
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Solna, 171 64, Sweden
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Uppsala, SE-751 85, Sweden