New combo therapy shows promise for bile duct cancer
NCT ID NCT05771480
First seen Jun 25, 2026 · Last updated Jul 30, 2026 · Updated 3 times
Summary
This phase 3 trial is testing whether adding the immunotherapy drug durvalumab to standard chemotherapy can help people with advanced biliary tract cancer (a type of bile duct cancer). About 142 participants will receive the combination, and researchers will track side effects, survival, and tumor shrinkage. The goal is to find a more effective first-line treatment for this hard-to-treat cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- durvalumab (an immunotherapy drug) combined with gemcitabine-based chemotherapy
- What this could lead to
- If successful, this combination could become a new standard first-line treatment, helping people with advanced biliary tract cancer live longer and control their disease better.
- What could go wrong
- This is a single-arm, open-label study without a placebo group, so results may be less definitive. Side effects like severe immune reactions or infections are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Research Site
Mobile, Alabama, 36607, United States
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Research Site
Orange, California, 92868, United States
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Research Site
Washington D.C., District of Columbia, 20007, United States
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Research Site
Portland, Oregon, 97213, United States
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Research Site
Clichy, 92110, France
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Research Site
Dijon, 21079, France
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Research Site
Montpellier, 34090, France
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Research Site
Villejuif, 94800, France
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Research Site
Chemnitz, 09131, Germany
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Hanover, 30625, Germany
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Research Site
Castelfranco Veneto, 31033, Italy
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Research Site
Foggia, 71122, Italy
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Palermo, 90146, Italy
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Pisa, 56126, Italy
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Rozzano, 20089, Italy
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Research Site
Chūōku, 104-0045, Japan
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Research Site
Kanazawa, 920-8641, Japan
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Research Site
Kashiwa, 227-8577, Japan
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Kyoto, 606-8507, Japan
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Research Site
Osaka, 541-8567, Japan
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Research Site
Sendai, 980-8574, Japan
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Research Site
Ube, 755-8505, Japan
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Research Site
Wakayama, 641-8509, Japan
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Research Site
Yokohama, 241-8515, Japan
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Research Site
Singapore, 169610, Singapore
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Research Site
Seoul, 03080, South Korea
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Research Site
Seoul, 05505, South Korea
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Research Site
Seoul, 06351, South Korea
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Research Site
Barcelona, 08035, Spain
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Research Site
Madrid, 28027, Spain
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Research Site
Madrid, 28040, Spain
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Research Site
Madrid, 28041, Spain
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Research Site
Pamplona, 31008, Spain
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Research Site
Seville, 41013, Spain
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A new test could reveal how radiation affects the liver
- Can a smart drug home in on Hard-to-Treat cancers?
- Can a new immunotherapy combo shrink Hard-to-Treat tumors?
- Can blood tests reveal how liver and bile duct cancers respond to treatment?
- Can a smart drug home in on Hard-to-Treat GI cancers?
- Can matching drugs to tumor genes beat biliary cancer?