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Special MRI may reveal invisible brain injury in concussed athletes

NCT ID NCT06144359

Diagnosis Sponsor: University Hospital, Clermont-Ferrand Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 04, 2026 · Last updated Sep 04, 2026

Summary

Researchers are testing whether a special type of MRI, called diffusion tensor imaging, can detect subtle damage to the brain's white matter after a sports concussion. Standard brain scans often look normal after a concussion, even when athletes have lingering symptoms. This study will compare brain scans of about 59 people, including athletes who had a concussion within the past week and healthy volunteers of similar age and sex. The goal is to see if DTI can reveal structural changes that might help predict recovery and guide when it is safe to return to play.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Diffusion tensor imaging (DTI) MRI at 3 Tesla
What this could lead to
If DTI detects subtle brain damage invisible on standard scans, it could give doctors an objective tool to diagnose concussions and guide return-to-play decisions.
What could go wrong
This is a small, early study, and previous research on DTI after concussion has shown conflicting results. The technique may not reliably distinguish injured from healthy brains.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

59 people

The number who actually took part.

Started

Oct 2023

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Cases: Sports patients with concussion in sport, seen in Sports Medicine consultation within 7 days of concussion. * Healthy controls: major case matched subjects by sex and age (± 5 years). * For all: people with health insurance Exclusion Criteria: * For all: major minor or incapacitated people, with a history of neurological or psychiatric disease, people who have had concussions in the past, pregnant or breastfeeding women, protected persons (guardianship, curatorship, safeguard of justice), contraindication to MRI.

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Conditions

The condition(s) this trial relates to.

Brain Concussion traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Concussion, brain

Contacts and locations

Locations

  • CHU Clemront-Ferrand

    Clermont-Ferrand, 63000, France

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