New eye drop cocktail aims to quench dry eye Sufferers' tears

NCT ID NCT07128628

Completed Symptom relief Sponsor: Bausch & Lomb Incorporated Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This Phase 2 trial tests a new eye drop that combines two active ingredients—lifitegrast and perfluorohexyloctane—for people with dry eye disease. About 423 adults will use the drops twice daily for 4 weeks. Researchers will measure changes in eye surface staining and symptom scores to see if the combo works better than either ingredient alone or a placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lifitegrast and perfluorohexyloctane eye drops
What this could lead to: If it works, this could offer a more effective twice-daily eye drop for dry eye symptoms like stinging and blurred vision.
What could go wrong: This is an early Phase 2 trial with only 4 weeks of treatment, so long-term benefits are unknown. The new combo may not work better than existing drops.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

dry eye syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DRY EYE DISEASE

Contacts and locations

Locations

Advancing Vision Research, LLC

Smyrna, Tennessee, 37167, United States
Asheville Eye Associates

Asheville, North Carolina, 28803, United States
Bowden Eye and Associates

Jacksonville, Florida, 32256, United States
CORE Inc.

Shelby, North Carolina, 28150, United States
Clayton Eye Clinical Research, LLC

Morrow, Georgia, 30260, United States
Complete Eye Care of Medina

Medina, Minnesota, 55340, United States
Comprehensive Eye Care Ltd.

Washington, Missouri, 63090, United States
Eye Doctors of Arizona, PLLC

Phoenix, Arizona, 85028, United States
Eye Research Foundation, Inc.

Newport Beach, California, 92663, United States
Global Research Management, Inc.

Glendale, California, 91204, United States
Insight Eyecare Specialties, Inc.

Kansas City, Missouri, 64111, United States
Insight Research Clinic LLC.

Powell, Ohio, 43065, United States
Intouch Clinical Research Center

Houston, Texas, 77034, United States
Kannarr Eye Care, LLC

Pittsburg, Kansas, 66762, United States
Lake Travis Eye and Laser Center

Lakeway, Texas, 78738, United States
LoBue Laser and Eye Medical Center

Murrieta, California, 92562, United States
Midwest Cornea Associates LLC

Carmel, Indiana, 46032, United States
Moyes Eye Center, P.C.

Kansas City, Missouri, 64154, United States
Oculus Research

Garner, North Carolina, 27529, United States
Ophthalmology Consultants, Ltd.

St Louis, Missouri, 63131, United States
Opthalmic consultants of Long Island

Garden City, New York, 11530, United States
Rochester Ophthalmological Group,PC

Rochester, New York, 14618, United States
Scott & Christie Eyecare Associates - The Surgery Center at Cranberry

Cranberry Township, Pennsylvania, 16066, United States
Segal Drug Trials/Office of Bruce A Segal, MD

Delray Beach, Florida, 33484, United States
Shettle Eye Research, Inc

Largo, Florida, 33773, United States
SoCal Eye - Lakewood Clinic

Long Beach, California, 90805, United States
Southern College of Optometry

Memphis, Tennessee, 38104, United States
Total Eye Care PA

Memphis, Tennessee, 38119, United States
Vance Thompson Vision - Alexandria

Alexandria, Minnesota, 56308, United States
Vance Thompson Vision - Fargo, ND

West Fargo, North Dakota, 58078, United States
West Bay Eye Associates

Warwick, Rhode Island, 02888, United States
Wolstan and Goldberg Eye Associates

Torrance, California, 90505, United States

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