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Can a weekly antibiotic stop a Rainy-Season infection?

NCT ID NCT07865156

Prevention Sponsor: Chulalongkorn University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Oct 08, 2026 · Last updated Oct 09, 2026 · Updated 1 time

Summary

Researchers in Thailand are testing whether a weekly dose of the antibiotic doxycycline can prevent leptospirosis, a bacterial infection spread through water and soil contaminated by animal urine. The trial enrolls about 1,000 people at high risk of exposure, such as farmers and outdoor workers, during the rainy season. Participants receive either doxycycline or a placebo, and researchers track how many develop leptospirosis using lab tests. The goal is to see if this preventive approach lowers infection rates in high-risk groups.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
doxycycline, an antibiotic taken weekly as a preventive medicine
What this could lead to
If it works, weekly doxycycline could become a simple way to protect farmers and other high-risk workers from leptospirosis during rainy seasons.
What could go wrong
The trial may find that weekly doxycycline does not lower infection rates, or that side effects and antibiotic resistance outweigh the benefits. Results from Thailand may not apply to other regions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 1,000 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2026

An estimate. Start dates often move.

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * High-risk exposure typically refers to water or soil - particularly wet ground at workplace and/or contact with animal water reservoir Exclusion Criteria: * Body temperature higher than 38 °C * Patients were confirmed to have leptospirosis within 3 months * Pregnancy or breastfeeding * Allergy to doxycycline * Cirrhosis Child-Pugh C, acute hepatitis, persistent elevated liver enzymes AST/ALT \> 3 times * Doxycycline Interactions: phenytoin, carbamazepine, barbiturates, warfarin methotrexate, cyclosporin

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Conditions

The condition(s) this trial relates to.

leptospirosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chemoprophylaxis Leptospirosis

How to take part

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  1. The official record

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  2. A doctor treating you

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