Could a common antibiotic shrink NF2 skin tumors without surgery?

NCT ID NCT05521048

Ongoing Disease control Sponsor: Massachusetts Eye and Ear Infirmary Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether injecting doxycycline directly into skin schwannomas can shrink them in people with neurofibromatosis type 2 (NF2). Nineteen participants will receive up to three injections per tumor, with the dose based on tumor size. The goal is to find a less invasive alternative to surgery for these painful growths.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: doxycycline
What this could lead to: If it works, this could offer a non-surgical option to shrink painful skin tumors in people with NF2, reducing the need for surgery.
What could go wrong: This is a small early-phase trial with only 19 people, so results may not apply to everyone. The injections may not shrink tumors or could cause side effects like pain or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Neurofibromatosis 2 NF2-related schwannomatosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NEUROFIBROMATOSIS TYPE 2

Contacts and locations

Locations

Massachusetts Eye and Ear

Boston, Massachusetts, 02214, United States

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