Could a common antibiotic shrink NF2 skin tumors without surgery?
NCT ID NCT05521048
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether injecting doxycycline directly into skin schwannomas can shrink them in people with neurofibromatosis type 2 (NF2). Nineteen participants will receive up to three injections per tumor, with the dose based on tumor size. The goal is to find a less invasive alternative to surgery for these painful growths.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
doxycycline
What this could lead to
If it works, this could offer a non-surgical option to shrink painful skin tumors in people with NF2, reducing the need for surgery.
What could go wrong
This is a small early-phase trial with only 19 people, so results may not apply to everyone. The injections may not shrink tumors or could cause side effects like pain or infection.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Massachusetts Eye and Ear
Boston, Massachusetts, 02214, United States