Experimental drug AR-42 tested in brain tumor patients before surgery

NCT ID NCT02282917

First seen Jan 06, 2026 · Last updated Apr 29, 2026 · Updated 13 times

Summary

This early study tested an experimental drug called AR-42 in 7 adults with vestibular schwannoma or meningioma (brain tumors) who were already scheduled for surgery. Participants took the drug for 3 weeks before their tumor was removed, allowing researchers to measure how much drug reached the tumor and whether it affected a key protein (p-AKT). The goal was to gather information, not to treat the disease, so this study was exploratory and has ended.

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Contacts and locations

Locations

  • Johns Hopkins University

    Baltimore, Maryland, 21287, United States

  • Massachusetts Eye and Ear

    Boston, Massachusetts, 02214, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Stanford University

    Stanford, California, 94305, United States

Conditions

Explore the condition pages connected to this study.