Experimental drug AR-42 studied in rare brain tumors – early results show promise

NCT ID NCT02282917

First seen Jan 06, 2026 · Last updated Jun 10, 2026 · Updated 21 times

Summary

This early-phase study tested an experimental drug called AR-42 in 7 adults with vestibular schwannoma or meningioma who were already scheduled for tumor removal surgery. The goal was to see if the drug could reach the tumor and affect a specific protein linked to tumor growth. Participants took AR-42 for 3 weeks before surgery, and researchers measured drug levels and protein activity in the removed tumor tissue.

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Contacts and locations

Locations

  • Johns Hopkins University

    Baltimore, Maryland, 21287, United States

  • Massachusetts Eye and Ear

    Boston, Massachusetts, 02214, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Stanford University

    Stanford, California, 94305, United States

Conditions

Explore the condition pages connected to this study.