Brain chemical boost tested to lift fog of Late-Life depression

NCT ID NCT04469959

Summary

This study is testing if a medication that increases dopamine, a key brain chemical, can help older adults with depression who also experience slowed thinking and movement. Researchers will give participants either the medication (L-DOPA) or a placebo for short periods to see if it improves their mood, mental speed, and walking. The goal is to understand if targeting dopamine circuits offers a new way to manage this hard-to-treat condition.

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Contacts and locations

Locations

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15213, United States

  • Vanderbilt Psychiatric Hospital

    Nashville, Tennessee, 37212, United States

Conditions

Explore the condition pages connected to this study.