New drug trial targets dual brain proteins to slow lewy body dementia
NCT ID NCT07589595
First seen May 16, 2026 · Last updated May 16, 2026
Summary
This study tests whether the drug donanemab can slow down worsening of thinking and daily living skills in people with early cognitive decline who also have signs of Lewy body dementia and Alzheimer's-related brain changes. About 350 participants will receive either donanemab or a placebo for 1.5 years. The goal is to see if the drug helps preserve memory and function.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Axiom Brain Health LLC
Tampa, Florida, 33609, United States
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BRP-Kendal Lakes
Miami, Florida, 33175, United States
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Brain Matters Research
Delray Beach, Florida, 33445, United States
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CenExel Rocky Mountain Clinical Research
Englewood, Colorado, 80113, United States
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Central Texas Neurology Consultants
Round Rock, Texas, 78681, United States
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Chang Gung Medical Foundation-Linkou Branch
Taoyuan, 333, Taiwan
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Charter Research - Orlando
Orlando, Florida, 32803, United States
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Citizens Memorial Hospital District
Bolivar, Missouri, 65613, United States
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Conquest Research
Winter Park, Florida, 32789, United States
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EvergreenHealth
Kirkland, Washington, 98034, United States
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Ewha Womans University Mokdong Hospital
Seoul, 07985, South Korea
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Gadolin Research
Beaumont, Texas, 77702, United States
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Gangnam Severance Hospital, Yonsei University Health System
Gangnam-gu, 06273, South Korea
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Hanyang University Seoul Hospital
Seoul, 04763, South Korea
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Headlands Eastern MA LLC
Plymouth, Massachusetts, 02360, United States
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HonorHealth Research Institute
Scottsdale, Arizona, 85258, United States
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Houston Methodist Hospital
Houston, Texas, 77030, United States
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Hyogo Prefectural Harima-Himeji General Medical Center
Himeji, 670-8560, Japan
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Inage Neurology and Memory Clinic
Inage, 263-0043, Japan
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Indiana University Health Neuroscience Center
Indianapolis, Indiana, 46202, United States
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Inha University Hospital
Incheon, 22332, South Korea
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Irvine Clinical Research
Irvine, California, 92614, United States
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JEM Research Institute
Atlantis, Florida, 33462, United States
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Juntendo Tokyo Koto Geriatric Medical Center
Kōtoku, 136-0075, Japan
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K2 Medical Research - East Providence
East Providence, Rhode Island, 02914, United States
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K2 Medical Research ORLANDO
Maitland, Florida, 32751, United States
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Katayama Medical Clinic
Kurashiki, 710-0813, Japan
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Kerwin Medical Center
Dallas, Texas, 75231, United States
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Ki Health Partners, LLc, dba New England Institute for Clinical Research
Stamford, Connecticut, 06905, United States
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Kobe University Hospital
Kobe, 650-0017, Japan
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Konkuk University Medical Center
Seoul, 05030, South Korea
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Massachusetts General Hospital - Charlestown
Charlestown, Massachusetts, 02129, United States
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Mayo Clinic in Florida
Jacksonville, Florida, 32224, United States
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Mayo Clinic in Rochester, Minnesota
Rochester, Minnesota, 55905, United States
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Memory Clinic Ochanomizu
Bunkyō City, 113-0034, Japan
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Memory Clinic Toride
Toride, 302-0004, Japan
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Nagoya University Hospital
Nagoya, 466-8560, Japan
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National Center for Geriatrics and Gerontology
Ōbu, 474-8511, Japan
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National Cheng Kung University Hospital
Tainan, 704, Taiwan
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National Taiwan University Hospital
Taipei, 10002, Taiwan
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Neurology Center of New England
Foxborough, Massachusetts, 02035, United States
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Neuropsychiatric Research Center of Southwest Florida
Fort Myers, Florida, 33912, United States
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New Taipei Municipal TuCheng Hospital
New Taipei City, 236, Taiwan
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Nippon Medical School Musashi Kosugi Hospital
Kawasaki, 211-8533, Japan
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Norman Fixel Institute for Neurological Diseases (FIND)
Gainesville, Florida, 32608, United States
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Oita University Hospital
Yufu, 879-5593, Japan
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Oregon Health and Science University
Portland, Oregon, 97239, United States
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Palm Beach Neurology
West Palm Beach, Florida, 33407, United States
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Pennsylvania Hospital
Philadelphia, Pennsylvania, 19107, United States
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Profound Research LLC
Carlsbad, California, 92011, United States
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QUEST Research Institute
Farmington Hills, Michigan, 48334, United States
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Re:Cognition Health
Fairfax, Virginia, 22031, United States
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Renstar Medical Research
Ocala, Florida, 34471, United States
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Severance Hospital, Yonsei University Health System
Seoul, 03722, South Korea
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Shonan Keiiku Hospital
Fujisawa, 252-0816, Japan
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St. Marianna University Hospital
Kawasaki, 216-8511, Japan
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Stanford Neuroscience Health Center
Palo Alto, California, 94304, United States
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Struthers Parkinson's Center
Golden Valley, Minnesota, 55427, United States
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Summit Headlands
Portland, Oregon, 97210, United States
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Tachikawa Hospital
Tachikawa, 190-8531, Japan
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Taipei Medical University Shuang Ho Hospital
New Taipei City, 235, Taiwan
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Taipei Veterans General Hospital
Taipei, 11217, Taiwan
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The University of Kansas - Clinical Research Center
Fairway, Kansas, 66205, United States
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The University of Texas Health Science Center
San Antonio, Texas, 78229, United States
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The University of Texas Health Science Center at Houston
Houston, Texas, 77054, United States
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Tokyo Metropolitan Institute for Geriatrics and Gerontology
tabashi City, 173-0015, Japan
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TrialSphere Corp
Chandler, Arizona, 85286, United States
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UCSD - Altman Clinical and Translational Research Institute (ACTRI)
La Jolla, California, 92037, United States
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VIN - Aventura
Aventura, Florida, 33180, United States
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Yokohama Minami Kyosai Hospital
Yokohama, 236-0037, Japan
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Conditions
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