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Can a new chemo schedule tame side effects in prostate cancer?

NCT ID NCT05676203

Ongoing Disease control Sponsor: Jena University Hospital Source: ClinicalTrials.gov ↗

First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time

Summary

This phase 3 trial is testing whether giving the chemotherapy drug docetaxel more often but at a lower dose—every 2 weeks instead of every 3 weeks—can reduce severe side effects in men with metastatic hormone-sensitive prostate cancer. All participants also receive the standard combination of darolutamide and hormone therapy. The study tracks how many men experience serious side effects, as well as PSA levels and time until the cancer becomes resistant to hormone therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Docetaxel (chemotherapy) given in two different schedules, combined with darolutamide and androgen deprivation therapy (ADT)
What this could lead to
If successful, this could identify a safer chemotherapy schedule that reduces severe side effects while maintaining effectiveness for men with metastatic prostate cancer.
What could go wrong
The trial is still in progress, and results may not show a clear difference between schedules. Chemotherapy can cause serious side effects like infections and nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

metastatic prostate carcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC HORMONE-SENSITIVE PROSTATE CANCER (MHSPC)

Contacts and locations

Locations

  • Brüderkrankenhaus

    Trier, 54292, Germany

  • Brüderkrankenhaus St- Josef Paderborn

    Paderborn, North Rhine-Westphalia, 33098, Germany

  • Helios Klinikum Erfurt

    Erfurt, 99089, Germany

  • Helios Universitätsklinikum Wuppertal

    Wuppertal, 42283, Germany

  • KEM | Evang. Kliniken Essen-Mitte

    Essen, 45136, Germany

  • Klinikum Nürnberg

    Nuremberg, 90419, Germany

  • Klinikum Wetzlar

    Wetzlar, Hesse, 35578, Germany

  • Krankenhaus Martha-Maria Halle Dölau gGmbH

    Halle, Saxony-Anhalt, 06120, Germany

  • Krankenhaus Nordwest

    Frankfurt am Main, 60488, Germany

  • Krankenhaus der Barmherzigen Brüder

    Vienna, Austria, 1020, Austria

  • LMU Klinikum

    München, 81377, Germany

  • Marien Krankenhaus

    Bergisch Gladbach, 51465, Germany

  • Med. Hochschule Hannover

    Hanover, Lower Saxony, 30625, Germany

  • Nationales Centrum für Tumorerkrankungen (NCT) Heidelberg

    Heidelberg, Baden-Wurttemberg, 69120, Germany

  • Ordensklinikum Linz GmbH, Elisabethinen

    Linz, Austria, 4020, Austria

  • Praxisgemeinschaft f. Onkologie & Urologie

    Wilhelmshaven, Schleswig-Holstein, 26389, Germany

  • St. Anna Hospital Herne

    Herne, 44625, Germany

  • St. Theresien Krankenhaus Nürnberg

    Nuremberg, 90491, Germany

  • Studienpraxis Urologie

    Nürtingen, 72622, Germany

  • Städtisches Klinikum Dessau

    Dessau, 06847, Germany

  • TUM Klinikum

    München, 81675, Germany

  • UROLOGIE BAYENTHAL Gemeinschaftspraxis

    Cologne, Germany

  • Uniklinikum Erlangen

    Erlangen, 91054, Germany

  • Uniklinikum Würzburg

    Würzburg, 97080, Germany

  • University Hospital Jena, Department of Urology

    Jena, Thuringia, 07747, Germany

  • Universitäts Klinikum Frankfurt

    Frankfurt am Main, 60590, Germany

  • Universitätsklinikum Bonn

    Bonn, 53127, Germany

  • Universitätsklinikum Düsseldorf

    Düsseldorf, 40225, Germany

  • Universitätsklinikum Essen

    Essen, 45147, Germany

  • Universitätsklinikum Giessen und Marburg GmbH, Standort Giessen

    Giessen, 35392, Germany

  • Universitätsklinikum Gießen und Marburg - Standort Marburg

    Marburg, 35043, Germany

  • Universitätsklinikum Hamburg-Eppendorf

    Hamburg, Germany

  • Universitätsklinikum Magdeburg

    Magdeburg, 39120, Germany

  • Universitätsklinikum Münster

    Münster, 48149, Germany

  • Universitätsklinikum Schleswig-Holstein - Campus Lübeck

    Lübeck, Germany

  • Universitätsklinikum Tübingen

    Tübingen, 72076, Germany

  • Universitätsklinikum Ulm

    Ulm, 89081, Germany

  • Universitätsmedizin Mannheim

    Mannheim, 68167, Germany

  • Urologicum Duisburg

    Duisburg, North Rhine-Westphalia, 47169, Germany

  • Urologie Schlosscarree

    Braunschweig, 38100, Germany

  • Urologische Klinik München Planegg

    Planegg, München, 82152, Germany

  • Urologisches Zentrum Euregio

    Würselen, North Rhine-Westphalia, 52146, Germany

  • Vivantes Prostatazentrum im Klinikum am Urban

    Berlin, State of Berlin, 10967, Germany

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