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Can a common steroid stretch spinal anesthesia and keep surgery patients comfortable longer?

NCT ID NCT07819682

Symptom relief Sponsor: Holy Family Hospital, Pakistan Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 15, 2026 · Last updated Sep 16, 2026 · Updated 1 time

Summary

Researchers are testing whether an intravenous dose of the steroid dexamethasone makes spinal anesthesia last longer in adults having lower abdominal or orthopedic surgery. Participants receive either 8 mg of dexamethasone in saline or a plain saline placebo before their spinal injection of bupivacaine. The team then measures how long numbness and muscle weakness last and how much pain patients feel four hours after surgery. The goal is to see if the steroid delays the return of sensation and the need for additional pain relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dexamethasone, a steroid given intravenously before spinal anesthesia
What this could lead to
If it works, adding a steroid to spinal anesthesia could extend numbness and pain relief after lower abdominal surgery, possibly delaying the need for extra painkillers.
What could go wrong
This is a single-center study of 110 adults with mild health status, so results may not apply to sicker patients or other hospitals. Steroids can raise blood sugar and slightly increase infection risk, and the effect on block duration may be small or absent.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 110 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients undergoing lower abdominal surgeries and orthopaedic surgeries including pelvic and lower extremity surgeries * Patients classified as American Society of Anesthesiologists (ASA) physical status I or II Exclusion Criteria: * Patients with a history of spinal surgery, spinal instrumentation, or previous failed spinal anaesthesia * Patients with pre-existing neurological disorders, peripheral neuropathy, or sensory/motor deficits * Patients with known hypersensitivity or allergy to local anaesthetic agents or dexamethasone * Patients with congenital spinal deformities or acquired spinal conditions such as advanced spondylosis or kyphoscoliosis that may interfere with neuraxial block * Patients with contraindications to spinal anaesthesia, including coagulopathy, local infection at the injection site, or raised intracranial pressure * Patients with diabetes mellitus, chronic steroid therapy, immunosuppression, or systemic infection (due to steroid use) * Pregnant patients or those undergoing emergency surgeries

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adjuvant Dexamethasone Spinal anesthesia

How to take part

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  1. The places running it

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  2. The official record

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Contacts and locations

Locations

  • Holy Family Hospital

    RECRUITING

    Rawalpindi, Punjab Province, 46000, Pakistan

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