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Can a patient's own blood proteins help dental implants heal better?

NCT ID NCT07725029

Disease control Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This trial tests two bone-grafting materials placed around dental implants immediately after tooth extraction in the front upper jaw. One group receives a graft made from processed tooth dentin, while the other gets dentin mixed with a concentrate of the patient's own blood proteins (platelet-rich fibrin). The goal is to see which approach leads to better implant stability during healing.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
demineralized dentin matrix with or without injectable platelet-rich fibrin
What this could lead to
If adding platelet-rich fibrin improves bone healing, it could lead to stronger, longer-lasting dental implants in the aesthetic zone.
What could go wrong
This is a small, early-stage trial with only 32 participants, so results may not apply broadly. Graft materials can sometimes fail to integrate or cause infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

32 people

The number who actually took part.

Started

Jun 2025

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient age ranged between 18-40 years old. * Patients seeking to replace non-restorable tooth / teeth in maxillary esthetic zone (anterior \&premolars) by using immediate implant placement. * Cooperative patients with high motivation and good oral hygiene. * Intact socket wall after tooth extraction. * Jumping gap more than 2mm. * Favorable occlusion without presence of parafunctional habits, eg; bruxism and clenching. * Sufficient inter-arch space to accommodate the future prothesis. * Patients able to comply with the required recall visits. Exclusion Criteria: * Patients with known systemic diseases, which can affect normal bone formation or blood coagulation. * Presence of signs of acute infection or pus formation. * Pregnancy. * Smoking. * Patients on bisphosphonate drug.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Tooth extraction

Contacts and locations

Locations

  • Mansoura

    Al Mansurah, Egypt

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