Bone-Saving shot may protect against fractures after gastric bypass

NCT ID NCT04087096

First seen Oct 31, 2025 · Last updated May 25, 2026 · Updated 26 times

Summary

This study tested whether denosumab, a drug used for osteoporosis, can prevent the rapid bone loss that often happens after weight-loss surgery. It included 36 postmenopausal women and men aged 50 or older who were planning either gastric bypass or sleeve gastrectomy. Participants received denosumab or a placebo, and researchers measured changes in hip bone density over time.

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Contacts and locations

Locations

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • University of California, San Francisco

    San Francisco, California, 94143, United States

Conditions

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