New drug combo shows promise in Hard-to-Treat cancers

NCT ID NCT05651022

First seen Jan 17, 2026 · Last updated May 16, 2026 · Updated 16 times

Summary

This early-phase study tests an experimental drug called DECOY20, given alone or with another drug (tislelizumab), in about 120 adults with advanced solid tumors like liver, colorectal, pancreatic, lung, head and neck, bladder, or MSI-high cancers. The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. This is not a cure; it aims to control the disease.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Atlantic Health System

    Morristown, New Jersey, 07960, United States

  • Cleveland Clinic Taussig Cancer Center

    Cleveland, Ohio, 44195, United States

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19111, United States

  • Gabrail Cancer & Research Center

    Canton, Ohio, 44718, United States

  • Hoag Memorial Hospital Presbyterian

    Newport Beach, California, 92663, United States

  • Prisma Health Cancer Institute-ITOR

    Greenville, South Carolina, 29605, United States

  • Roswell Park Comprehensive Cancer Center

    Buffalo, New York, 14263, United States

  • The Barbara Ann Karmanos Cancer Institute

    Detroit, Michigan, 48201, United States

  • UH Seidman Cancer Center

    Cleveland, Ohio, 44106, United States

  • University of Southern California- Norris Cancer Center

    Los Angeles, California, 90033, United States

  • Washington University, Siteman Cancer Center

    St Louis, Missouri, 63108, United States

  • Winship Cancer Institute of Emory University

    Atlanta, Georgia, 30322, United States

Conditions

Explore the condition pages connected to this study.