How far should surgeons go? a trial tests deeper lymph node removal for colon cancer

NCT ID NCT04364373

NEW Recruiting now Disease control Sponsor: Russian Society of Colorectal Surgeons Source: ClinicalTrials.gov ↗

First seen Aug 17, 2026 · Last updated Aug 17, 2026

Summary

This trial asks whether removing a wider set of lymph nodes (D3) during left colon cancer surgery improves 5-year survival compared to the standard removal (D2). It enrolls about 1,381 people with adenocarcinoma located between the splenic flexure and rectosigmoid junction. Researchers will also compare safety and functional outcomes to see if the more extensive surgery is worth it.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Surgical procedure comparing D2 (standard) vs D3 (extended) lymph node dissection during left colon resection
What this could lead to: If D3 dissection proves better, it could become the preferred surgical approach for left colon cancer, potentially improving long-term survival.
What could go wrong: The trial is large but results are awaited; D3 may not improve survival and could carry higher surgical risks, such as bleeding or nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colon carcinoma colonic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLON CANCER

Contacts and locations

Locations

Clinic of coloproctology and minimally invasive surgery
RECRUITING

Moscow, 119435, Russia

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