New gel could slash infection risk after colon surgery

NCT ID NCT03633123

Completed Prevention Sponsor: PolyPid Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a gel called D-PLEX, applied directly to the surgical wound during abdominal surgery, to see if it could prevent infections. Half of the 202 participants received the gel plus standard care, and the other half received standard care alone. The main goal was to measure infection and death rates within 30 days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: D-PLEX (a gel applied to the surgical wound during surgery)
What this could lead to: If successful, D-PLEX could become a standard addition to surgery to lower the risk of serious wound infections.
What could go wrong: This is a mid-stage trial with 202 people, so results may not hold in larger studies. The gel is new and long-term safety is not yet known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ABDOMINAL SURGERY COLON SURGERY POST-OP INFECTION

Contacts and locations

Locations

Assaf-Harofeh MC

Zrifin, Israel
Assuta Ramat-HaHayal

Tel Aviv, Israel
Kaplan MC

Rehovot, Israel
Meir MC

Kfar Saba, Israel
Rabin MC, Campus Beilinson

Petah Tikva, Israel
Sheba MC, Tel-Hashomer

Ramat Gan, Israel
Tel-Aviv Sourasky MC

Tel Aviv, Israel
Wolfson MC

Holon, Israel

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