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Breathing test may help doctors give right amount of fluids

NCT ID NCT03780660

Diagnosis Sponsor: University Hospital, Lille Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether changes in central venous pressure (CVP) during breathing can predict if ICU patients need more fluids. 68 spontaneously breathing patients were monitored. The goal was to find a simple way to avoid giving too much or too little fluid, which can be harmful.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could give doctors a simple, non-invasive way to decide which patients need extra fluids, potentially reducing harm from over- or under-hydration.
What could go wrong
This is a small, completed study with only 68 patients, so results may not apply to all ICU patients. The method may not be accurate enough for routine use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

68 people

The number who actually took part.

Started

Mar 2019

Finished

Sep 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patient hospitalized in one of intensive care unit of Roger Salengro university hospital CHU Lille

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Spontaneous breathing without mechanical assistance * Central venous catheter (superior vena cava) and monitoring of central venous pressure * Urinary catheter and monitoring of intra-abdominal pressure Exclusion Criteria: * Intolerance to ventilatory manœuvre including Severe basal dyspnea/Symptomatic heart failure (pulmonary edema) * Contraindication to passive leg raising (intracranial hypertension) * Passive leg raising unsuitable for measuring hemodynamic response : High grade aortic insufficiency/ Poor echogenicity unsuitable to measure the velocity-time /integral of aortic blood flow/ Pregnancy/Abdominal hypertension with abdominal compartment syndrome/ Lower leg amputation * Necessity of urgent hemodynamic therapy (within 90 min) * Modification of hemodynamic therapy during study protocol (vascular filling, increase catecholamine dose

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Conditions

The condition(s) this trial relates to.

Respiratory Aspiration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Breathing

Contacts and locations

Locations

  • Hôpital Roger Salengro, CHU

    Lille, France

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