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Blood test spots hidden cancer; new drug aims to stop it

NCT ID NCT06680596

ENROLLING_BY_INVITATION Disease control Sponsor: UNICANCER Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated May 04, 2026 · Updated 24 times

Summary

This study screens people with HR-positive, HER2-low metastatic breast cancer who are taking a CDK4/6 inhibitor. If a blood test still finds cancer DNA after one month, they receive the targeted drug trastuzumab deruxtecan (T-DXd). The goal is to see if T-DXd can delay cancer growth. About 80 adults will take part in this phase 2 trial.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Centre Antoine Lacassagne

    Nice, 06189, France

  • Centre Eugene Marquis

    Rennes, France

  • Centre Hospitalier Alpes Léman

    Contamine-sur-Arve, 74130, France

  • Centre Hospitalier D'Auxerre

    Auxerre, 89000, France

  • Centre Hospitalier William Morey

    Chalon-sur-Saône, 71100, France

  • Centre Hospitalier de Beauvais

    Beauvais, 60021, France

  • Centre Hospitalier de Cholet

    Cholet, 49300, France

  • Centre Hospitalier de Pau

    Pau, 64046, France

  • Centre Hospitalier de la Côte Basque

    Bayonne, 64100, France

  • Centre Jean Perrin

    Clermont-Ferrand, 63011, France

  • Centre Léon Bérard

    Lyon, 69008, France

  • Chd Vendée

    La Roche-sur-Yon, 85925, France

  • Chi Fréjus-Saint-Raphaël

    Fréjus, 83608, France

  • Chp Saint-Grégoire - Groupe Vivalto Sante

    Saint-Grégoire, 35760, France

  • Chu Amiens Picardie

    Amiens, 80054, France

  • Chu de Brest - Hôpital Cavale Blanche

    Brest, 29200, France

  • Clinique Pasteur Lanroze - Cfro - Groupe Vivalto Sante

    Brest, 29200, France

  • Clinique Sainte-Anne - Gh Saint-Vincent

    Strasbourg, 67000, France

  • Clinique de L'Europe Amiens - Cthe

    Amiens, 80090, France

  • Clinique de La Sauvegarde

    Lyon, 69009, France

  • Groupe Hospitalier Diaconesses Croix Saint-Simon

    Paris, 75020, France

  • Gustave Roussy

    Villejuif, France

  • Hopital Prive Jean Mermoz

    Lyon, 69008, France

  • Hopital Privé Des Côtes D'Armor (Hpca) - Cario

    Plérin, 22190, France

  • Hôpital Saint-Louis

    Paris, 75010, France

  • Hôpital Simone Veil de Blois

    Blois, 41000, France

  • Hôpitaux Du Léman

    Thonon-les-Bains, 74200, France

  • Icm Val D'Aurelle

    Montpellier, 34298, France

  • Institut Godinot

    Reims, 51100, France

  • Institut Paoli Calmettes

    Marseille, 13009, France

  • Institut de Cancerologie de Lorraine

    Vandœuvre-lès-Nancy, 054519, France

  • Medipôle de Nancy - Cog-Ilc (Polyclinique de Gentilly)

    Nancy, 54100, France

  • Pôle Santé République (Elsan)

    Clermont-Ferrand, 63000, France

  • Sainte Catherine Institut Du Cancer Avignon Provence

    Avignon, 84918, France

Conditions

Explore the condition pages connected to this study.

BREAST CANCER METASTATIC BREAST CANCER STAGE IV