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CT scan could reveal whether leg surgery restores foot blood flow

NCT ID NCT05575778

Diagnosis Sponsor: Fudan University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

This trial tests whether a special CT scan, called CT perfusion, can measure blood flow in the feet of people with critical limb ischemia, a severe blockage of leg arteries. Researchers will scan 80 patients before and three days after they undergo surgery to restore blood flow. They will track how the scan readings change and follow patients for a year to see if those changes predict major complications like amputation or heart events.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
computed tomographic perfusion imaging
What this could lead to
If it works, CT perfusion could help doctors predict which patients benefit most from revascularization surgery and detect early signs of limb-threatening complications.
What could go wrong
This is a small, early diagnostic study. The imaging technique may not reliably predict outcomes, and results may not apply to all patients with critical limb ischemia.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

80 people

The number who actually took part.

Started

Oct 2022

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

patients with critical limb ischemia, who completed both pre- and post-operative CTP workups

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 to 80 years old; * CLI patients with Fontaine grade III-IV or Rutherford grade 4-6 and underwent a successful revascularization; * Patients completed both pre- and post-operative CTP workups; * Patients signed the informed consent form and be able to complete the clinical follow-up for 12 months. Exclusion Criteria: * Patients has participated in other clinical studies; * Patients with Heart failure (NYHA III/IV)/right to left shunt heart disease/severe aortic and mitral insufficiency/acute coronary syndrome/malignant arrhythmia/severe pulmonary hypertension (pulmonary artery pressure at least 90 mmHg)/moderate to severe renal insufficiency (creatinine clearance rate\<60 ml/min) * Any allergic constitution; * Pregnancy and childbirth; * Life expectancy\<12 months.

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Conditions

The condition(s) this trial relates to.

Chronic Limb-Threatening Ischemia limb ischemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Critical limb ischemia

Contacts and locations

Locations

  • Hua Dong Hospital Affiliated to Fu Dan University

    Shanghai, China

More trials for these conditions

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